Zwilling B S, Davis G W
Cancer Res. 1980 Oct;40(10):3455-8.
The effect of a single systemic or intratracheal administration of viable Mycobacterium bovis strain Bacillus Calmette-Guérin on the development of primary lung cancer in Syrian golden hamsters was assessed. M. bovis strain Bacillus Calmette-Guérin administered i.v. prior to, during, or after carcinogen treatment did not alter the incidence of lung tumors. Animals receiving intratracheal M. bovis strain Bacillus Calmette-Guérin had an increased incidence of lung tumors. Both i.v. and intratracheal routes accelerated the appearance of tumors.
评估了单次全身或气管内给予活的牛分枝杆菌卡介苗菌株对叙利亚金仓鼠原发性肺癌发生发展的影响。在致癌物处理之前、期间或之后静脉注射牛分枝杆菌卡介苗菌株，并未改变肺肿瘤的发生率。接受气管内注射牛分枝杆菌卡介苗菌株的动物肺肿瘤发生率增加。静脉注射和气管内注射途径均加速了肿瘤的出现。
