Lv Jian-Hua, Yao Lan, Li Shi-Yu, Ye Ming-Yu, Li Dan, Li Chang-Tian, Li Yu
Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun, PR China.
College of Life Sciences, Hebei Normal University, Shijiazhuang, PR China.
Nat Prod Res. 2025 Jul;39(13):3745-3750. doi: 10.1080/14786419.2024.2312428. Epub 2024 Feb 8.
Three new griseofulvin derivatives, griseofulvinoside A-C (-), were isolated from the ethyl acetate extract of the solid fermentation product of . Their structures were elucidated based on extensive spectroscopic data analysis of MS, 1D and 2D NMR. The antifungal activities of new compounds were evaluated against four phytopathogenic fungi , and all test compounds demonstrated inhibitory effects. Among them, compound exhibited the most potent activities against the four selected phytopathogenic fungi with inhibitory rates ranging from 40.2 to 75.8% at 0.2 mg/mL.
从[具体名称]固体发酵产物的乙酸乙酯提取物中分离出三种新的灰黄霉素衍生物,即灰黄霉素糖苷A - C(-)。基于质谱(MS)、一维和二维核磁共振(1D和2D NMR)的广泛光谱数据分析阐明了它们的结构。评估了新化合物对四种植物病原真菌的抗真菌活性,所有测试化合物均表现出抑制作用。其中,化合物在0.2mg/mL时对四种选定的植物病原真菌表现出最有效的活性,抑制率在40.2%至75.8%之间。