一种新的灰黄霉素衍生物来自软珊瑚来源真菌 sp. SCSIO41208。
A new griseofulvin derivative from a soft coral-derived fungus sp. SCSIO41208.
机构信息
School of Pharmacy, Guilin Medical University, Guilin, P. R. China.
Key Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, P. R. China.
出版信息
Nat Prod Res. 2020 Oct;34(20):2971-2975. doi: 10.1080/14786419.2019.1596093. Epub 2019 Apr 8.
A new griseofulvin derivative, eupenigriseofulvin (), together with six known compounds, griseofulvin (), dechlorogriseofluvin (), dechloroisogriseofulvin (), trichopyrone (), 2-(4-hydroxyphenyl)-ethanol (), and 1-phenylethane-1,2-diol (), were isolated from the EtOAc extract of sp. SCSIO41208. The structures of these compounds were elucidated by spectroscopic methods including NMR and mass spectrometry. The absolute configuration of was determined on the basis of electronic circular dichroism (ECD) data analysis.
从 sp. SCSIO41208 的 EtOAc 提取物中分离得到一个新的灰黄霉素衍生物，eupenigriseofulvin ()，以及六个已知化合物，灰黄霉素 (), dechlorogriseofluvin (), dechloroisogriseofulvin (), trichopyrone (), 2-(4-羟基苯基)-乙醇 (), 和 1-苯乙烷-1,2-二醇 (). 这些化合物的结构通过包括 NMR 和质谱在内的光谱方法阐明。根据电子圆二色谱 (ECD) 数据分析确定了 的绝对构型。
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