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[日间过度嗜睡、中枢型睡眠呼吸暂停与强直性肌营养不良]

[Excessive daytime sleepiness, central type sleep apnea and myotonic dystrophy].

作者信息

Reimão R, Lemmi H, Bertorini T

出版信息

Arq Neuropsiquiatr. 1985 Dec;43(4):391-5. doi: 10.1590/s0004-282x1985000400009.

Abstract

Two cases of myotonic dystrophy with excessive daytime somnolence are described. All-night polysomnographic studies were performed revealing high number of central sleep apnea which triggered micro-arousals and awakenings leading to decrease of sleep efficiency as well as of stage 3, 4 and REM. Obstructive and mixed apneas were found in the normal range. Hypoxia was not present in both recordings. Central sleep apneas and its secondary excessive daytime sleepiness may indicate early signs of the central nervous system impairment related to myotonic dystrophy, as a multi-organ disease.

摘要

本文描述了两例伴有日间过度嗜睡的强直性肌营养不良病例。进行了整夜多导睡眠图研究,结果显示中枢性睡眠呼吸暂停次数较多,这引发了微觉醒和觉醒,导致睡眠效率以及3期、4期睡眠和快速眼动睡眠减少。阻塞性和混合性呼吸暂停处于正常范围。两次记录中均未出现低氧血症。中枢性睡眠呼吸暂停及其继发的日间过度嗜睡可能表明与强直性肌营养不良相关的中枢神经系统损害的早期迹象,强直性肌营养不良是一种多器官疾病。

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