van der Meché F G, Bogaard J M, van der Sluys J C, Schimsheimer R J, Ververs C C, Busch H F
Department of Neurology, University Hospital Rotterdam-Dijkzigt, The Netherlands.
J Neurol Neurosurg Psychiatry. 1994 May;57(5):626-8. doi: 10.1136/jnnp.57.5.626.
Daytime sleepiness is common in myotonic dystrophy and might be attributed to disturbed nocturnal breathing. Seventeen out of 22 patients complained of excessive daytime sleepiness, resembling "idiopathic hypersomnolence". Sleep apnoea might have contributed to daytime sleepiness in only three of 17 patients. Treatment with the central stimulant methylphenidate produced sustained benefit in seven out of 11 patients tested. Daytime sleepiness in myotonic dystrophy is usually caused by dysfunction of central sleep regulation and not by disturbed nocturnal breathing.
白天嗜睡在强直性肌营养不良中很常见，可能归因于夜间呼吸紊乱。22名患者中有17名抱怨白天过度嗜睡，类似于“特发性睡眠增多症”。睡眠呼吸暂停可能仅在17名患者中的3名中导致白天嗜睡。对11名接受测试的患者使用中枢兴奋剂哌醋甲酯治疗产生了持续的疗效。强直性肌营养不良中的白天嗜睡通常是由中枢睡眠调节功能障碍引起的，而非夜间呼吸紊乱所致。
