Centre Hospitalier Vétérinaire Atlantia, Nantes, France.
Centre Hospitalier Vétérinaire Atlantia, Nantes, France.
Vet Anaesth Analg. 2024 Mar-Apr;51(2):115-125. doi: 10.1016/j.vaa.2024.01.002. Epub 2024 Jan 17.
To perform a qualitative evaluation of the analgesic effects of magnesium in domestic animals, including its anaesthetic sparing effects.
All database searches were made using PubMed and Google Scholar. Studies published after 1990, evaluating the use of magnesium and reporting information on analgesia, in dogs, cats, horses, cows, goats and sheep were selected (last search in August 2023). A reference check in the selected papers was performed to identify any study which was omitted. The CERQual (Confidence in Evidence from Reviews of Qualitative research) approach was used to assess confidence and analyse the evidence.
A total of 20 studies relevant to the analgesic effects of magnesium in veterinary patients and two reviews were included. All were published after 2006. Of the 20, five studies provided information about analgesia in the postoperative period in dogs with heterogenous results. Magnesium added epidurally increased the duration of the sensory block in several species. Motor block was also observed when added to spinal analgesia. Results regarding volatile agents sparing effect were conflicting. Occasional moderate adverse effects were reported in dogs, such as nausea and vomiting, when administered as a bolus in conscious animals, and hypotension when administered intraperitoneally. Collapse was reported in horses after epidural administration.
The evidence of an analgesic effect of magnesium in veterinary patients remains scarce considering the paucity and low quality of published data. Further research may be helpful to establish the efficacy and indications of magnesium in multimodal analgesia in animals.
对镁在包括其麻醉节约效果在内的家畜中的镇痛效果进行定性评估。
使用 PubMed 和 Google Scholar 进行所有数据库搜索。选择了 1990 年后发表的评估镁的使用并报告有关镇痛的信息的研究，包括狗、猫、马、牛、山羊和绵羊（最后一次搜索是在 2023 年 8 月）。对选定论文进行了参考文献检查，以确定任何遗漏的研究。使用 CERQual（从定性研究综述中评估证据的信心）方法来评估置信度并分析证据。
共纳入 20 项与兽医患者镁的镇痛作用相关的研究和 2 篇综述，均发表于 2006 年后。其中 5 项研究提供了关于不同犬种术后镇痛的信息，但结果存在差异。镁硬膜外给药可增加几种动物感觉阻滞的持续时间。当添加到脊髓镇痛时，也观察到运动阻滞。关于挥发性麻醉剂节约效果的结果存在矛盾。在有意识的动物中静脉注射时，偶尔会报告狗出现中度不良反应，如恶心和呕吐，而腹腔内注射时会出现低血压。在马中硬膜外给药后出现了崩溃。
考虑到发表数据的缺乏和低质量，镁在兽医患者中的镇痛作用的证据仍然很少。进一步的研究可能有助于确定镁在动物多模式镇痛中的疗效和适应证。
