Kamei Júlia Marchatto, Maués Raissa Dias, de Oliveira Silva Gabriel, Machado Alessandra Helena, Hoshino Erika Megumi, Bacchiega Fabiana Menezes, Sena Laís Mota Furtado, Negrato Carlos Antonio
University of São Paulo - Bauru Campus (USP-Bauru), Alameda Dr. Octávio Pinheiro Brisolla, 9-75, Bauru, 17012-901, Brazil.
Allergy Asthma Clin Immunol. 2024 Feb 8;20(1):12. doi: 10.1186/s13223-024-00869-9.
According to the Th1/Th2 paradigm, the expansion of Th1-type clones in individuals with type 1 diabetes results in reduced Th2-type clones, preventing the development of atopic diseases and vice versa. However, there is no consensus regarding the direct or inverse relationship between autoimmune and atopic diseases.
The aim of this scoping review was to examine the knowledge gap about the possibility of coexistence of asthma and type 1 diabetes and determine the prevalence of this association.
A scoping review was conducted, following the proposal of the Joanna Briggs Institute. The Population, Concept, and Context strategy was used to formulate the guiding question. The proposed question was: "What is the prevalence of asthma in people with T1DM?" After excluding duplicate articles, analyzing titles and abstracts, and excluding articles that did not answer the guiding question, 17 articles remained and were included in this review.
Most of the articles selected conformed to the Th1/Th2 hypothesis, as the prevalence of asthma was lower in individuals with T1DM. However, similar or higher prevalence of asthma was found between cases and controls in few articles.
The prevalence of asthma in people with T1DM ranged from 1.7% to 23.1%. Maybe the mechanisms that characterizes the Th1/Th2 paradigm aren't as simple as just the interaction of certain cytokines, since Th1-mediated autoimmune diseases and Th2- mediated atopy can coexist.
根据Th1/Th2范式，1型糖尿病患者体内Th1型克隆的扩增会导致Th2型克隆减少，从而预防特应性疾病的发生，反之亦然。然而，关于自身免疫性疾病和特应性疾病之间的直接或反向关系尚无共识。
本范围综述的目的是探讨关于哮喘与1型糖尿病共存可能性的知识空白，并确定这种关联的患病率。
按照乔安娜·布里格斯研究所的提议进行了一项范围综述。采用人群、概念和背景策略来制定指导问题。提出的问题是：“1型糖尿病患者中哮喘的患病率是多少？”在排除重复文章、分析标题和摘要以及排除未回答指导问题的文章后，剩下17篇文章并纳入本综述。
大多数入选文章符合Th1/Th2假说，因为1型糖尿病患者中哮喘的患病率较低。然而，在少数文章中，病例组和对照组之间发现了相似或更高的哮喘患病率。
1型糖尿病患者中哮喘的患病率在1.7%至23.1%之间。也许表征Th1/Th2范式的机制并不像某些细胞因子的相互作用那么简单，因为Th1介导的自身免疫性疾病和Th2介导的特应性可以共存。
