Corwin-Buell Jennifer, Callahan Denise, McGrath Deborah, Millard Kimberly, Mosehauer Gary, Phatak Nitasha R
Vision Care, Bausch & Lomb Incorporated, Rochester, NY, USA.
Clin Ophthalmol. 2024 Feb 3;18:337-345. doi: 10.2147/OPTH.S445870. eCollection 2024.
This study was conducted to evaluate and compare the in vitro disinfection efficacies of six commercial lens cleaning and disinfecting products for planned replacement soft contact lenses.
Disinfection efficacies of five multi-purpose solutions (MPSs) and one hydrogen peroxide solution (HPS) as control were evaluated in the presence of organic soil according to the International Organization for Standardization (ISO, Geneva, Switzerland) ISO 14729 stand-alone test protocol. The five specified compendial organisms, three bacteria () and two fungi ( and ) were incubated with each solution under standard conditions, after which microbes were recovered and quantified.
Each of the solutions evaluated met or exceeded the standard's primary criteria (3-log reduction of bacteria and 1-log reduction of fungi) after incubation for the manufacturer-recommended soaking time, except for COMPLETE MPS, which achieved only 0.4 ± 0.1 average log reduction for . However, differences in efficacy between the solutions were noted. Average log reduction across all microbes for Biotrue Hydration Plus (4.6 ± 0.1) was comparable to that for CLEAR CARE PLUS HPS (4.3 ± 0.1) and greater than those for OPTI-FREE pure (3.6 ± 0.1), OPTI-FREE Replenish (4.0 ± 0.2), ACUVUE RevitaLens (3.9 ± 0.03), and COMPLETE MPS (3.6 ± 0.1). Biotrue Hydration Plus was especially effective at reducing the population of (4.2 ± 0.7-log reduction).
Products marketed for planned replacement soft CL disinfection generally meet the ISO 14729 standard's primary criteria for reducing populations of compendial organisms, with larger differences between solutions noted with .
本研究旨在评估和比较六种用于计划性更换软性接触镜的市售镜片清洁和消毒产品的体外消毒效果。
根据国际标准化组织（ISO，瑞士日内瓦）ISO 14729独立测试方案，在有有机污垢存在的情况下评估五种多功能护理液（MPS）和一种过氧化氢溶液（HPS，作为对照）的消毒效果。将五种指定的药典微生物，三种细菌（ ）和两种真菌（ 和 ）在标准条件下与每种溶液一起孵育，之后回收并定量微生物。
在按照制造商推荐的浸泡时间孵育后，除了全效MPS对 仅实现0.4±0.1的平均对数减少外，所评估的每种溶液均达到或超过了标准的主要标准（细菌减少3个对数，真菌减少1个对数）。然而，注意到各溶液之间的效果存在差异。博士伦水润护理液（4.6±0.1）对所有微生物的平均对数减少与清逸氧Plus过氧化氢溶液（4.3±0.1）相当，并且大于傲滴恒润（3.6±0.1）、傲滴乐明（4.0±0.2）、安视优恒润（3.9±0.03）和全效MPS（3.6±0.1）。博士伦水润护理液在减少 数量方面特别有效（减少4.2±0.7个对数）。
用于计划性更换软性接触镜消毒的市售产品通常符合ISO 14729标准中减少药典微生物数量的主要标准，对于 ，各溶液之间的差异更为明显。
