Gillies W E
Aust N Z J Ophthalmol. 1985 Nov;13(4):325-8. doi: 10.1111/j.1442-9071.1985.tb00442.x.
Sixty-eight cases (44 males, 24 females) of anterior segment pigment dispersal syndrome are reviewed. Five patients had no rise in intraocular pressure, 38 had ocular hypertension and 25 had glaucoma as shown by optic disc cupping and field loss. All cases had heavy deposition of pigment in the drainage angle together with Krukenberg spindles and/or light reflux through the iris. Other evidence of anterior segment pigment dispersal was common. The condition was commonest in young adult males, but could present at any age and in women. Medical treatment was often successful initially, but continued to control pressure in only 17 of 42 patients. Laser trabeculoplasty helped some patients. Drainage operations of various types were successful in 19 of 23 cases. Iris angiography showed evidence of vascular hypoperfusion of the iris which probably precedes pigment dispersal and suggests that the ultimate aetiology may be a congenital deficiency of the mesodermal support tissues of the iris. Some degree of iris stromal atrophy is also common and may become marked. Pigment dispersal from the pigment epithelium of the iris occurs in susceptible individuals and may be associated with the insertion of the dilator muscle. The term anterior segment pigment dispersal seems appropriate as the condition is limited to the anterior segment.
回顾了68例前段色素播散综合征患者（44例男性，24例女性）。5例患者眼压未升高，38例有高眼压症，25例有青光眼，表现为视盘杯状凹陷和视野缺损。所有病例的房角均有大量色素沉着，伴有 Krukenberg 梭和/或虹膜轻度色素反流。前段色素播散的其他表现很常见。该病在年轻成年男性中最常见，但可在任何年龄出现，女性也可发病。药物治疗起初往往有效，但在42例患者中只有17例能持续控制眼压。激光小梁成形术对部分患者有帮助。23例患者中有19例行各种类型的引流手术成功。虹膜血管造影显示虹膜存在血管灌注不足，这可能在色素播散之前出现，提示最终病因可能是虹膜中胚层支持组织的先天性缺陷。一定程度的虹膜基质萎缩也很常见，且可能会变得明显。虹膜色素上皮的色素播散发生在易感个体中，可能与瞳孔开大肌的附着有关。鉴于该病局限于前段，前段色素播散这一术语似乎恰当。
