Theophilo F, Markakis E, Theophilo L, Dietz H
Childs Nerv Syst. 1985;1(6):324-8. doi: 10.1007/BF00270817.
The author review 10 years' experience in managing brain abscess in childhood: 19 cases were treated in children from 1 to 18 years old. The etiology was rhinogenic in 5 cases, congenital heart disease in 5, hematogenous in 3, traumatic in 3, postoperative in 1, and unknown in 3 cases. Brain abscesses that developed by direct spread were located nearby the source, whereas metastatic abscesses (such as cardiogenic or hematogenous) in most cases spread via the vertebral-basilar system, usually developing in the parieto-occipital regions. Four of the 5 cases with multiple abscesses were cardiogenic and one hematogenous. The most important neurological signs were paresis (10 cases) and cranial nerve involvement (10 cases). Six abscesses were sterile and 6 grew aerobic and 6 anaerobic bacteria. In one case, aerobic as well as anaerobic bacteria were found. Fifteen patients were treated preoperatively with antibiotics. The treatment was operative in 17 cases. In two cases, gravely ill on admission, no surgical treatment was given. The etiology, localization, bacteriology, surgical methods, and results in those cases are discussed.
作者回顾了10年儿童脑脓肿的治疗经验:19例患儿年龄在1至18岁。病因方面,鼻源性5例,先天性心脏病5例,血源性3例,外伤性3例,术后1例,3例病因不明。直接蔓延形成的脑脓肿位于病灶附近,而转移性脓肿(如心源性或血源性)大多通过椎基底系统扩散,通常发生在顶枕区。5例多发脓肿中4例为心源性,1例为血源性。最重要的神经体征是轻瘫(10例)和脑神经受累(10例)。6例脓肿无菌,6例培养出需氧菌,6例培养出厌氧菌。1例同时发现需氧菌和厌氧菌。15例患者术前接受了抗生素治疗。17例进行了手术治疗。2例入院时病情严重,未接受手术治疗。文中讨论了这些病例的病因、定位、细菌学、手术方法及结果。