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社区药剂师使用神经营养性 B 族维生素联合治疗糖尿病周围神经病变的专家共识指南

Expert consensus guidelines for community pharmacists in the management of diabetic peripheral neuropathy with a combination of neurotropic B vitamins.

作者信息

Sathienluckana Thanompong, Palapinyo Sirinoot, Yotsombut Kitiyot, Wanothayaroj Ekgaluck, Sithinamsuwan Pasiri, Suksomboon Naeti

机构信息

Faculty of Pharmacy, Siam University, Bangkok, Thailand.

Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.

出版信息

J Pharm Policy Pract. 2024 Feb 7;17(1):2306866. doi: 10.1080/20523211.2024.2306866. eCollection 2024.

Abstract

This consensus guidance is for community pharmacists in diabetic peripheral neuropathy (DPN) management with a combination of neurotropic B vitamins. A multidisciplinary team including endocrinology, neurology, and pharmacy from Thailand discussed and aligned the practical scheme of DPN management in the community pharmacy setting, using the literature review and having face-to-face meeting. Five major statements have been endorsed as consensus recommendations for DPN care with strong acknowledgment. The aims of DPN management included reducing symptoms and the risk of complications, minimising adverse reactions from treatment regimens, and improving patients' knowledge and adherence to the treatment strategies. An initial screening process using a 7 items interview of Douleur Neuropathique 4 (DN4) questionnaire should be implemented to identify patients at risk of developing DPN. Subsequently, pharmacologic, and non-pharmacologic treatment should be employed based on patient-centered care. An interesting approach is combination of neurotropic B vitamins, which may be used as monotherapy or combination therapy to control DPN symptoms. The combined therapy potentially exhibits a synergistic effect and improves patient adherence. The consensus would be further considered in context of harmonisation of routine practice and country requirements.

摘要

本共识指南针对社区药师在使用神经营养性B族维生素联合治疗糖尿病周围神经病变(DPN)方面的情况。一个由泰国的内分泌学、神经学和药学专家组成的多学科团队,通过文献综述和面对面会议,讨论并确定了社区药房环境中DPN管理的实用方案。五项主要声明已被认可为DPN护理的共识性建议,并得到了强烈认可。DPN管理的目标包括减轻症状和并发症风险、将治疗方案的不良反应降至最低,以及提高患者对治疗策略的认知和依从性。应采用使用4项神经病理性疼痛问卷(DN4)的7项访谈进行初步筛查,以识别有发生DPN风险的患者。随后,应基于以患者为中心的护理采用药物和非药物治疗。一种有趣的方法是神经营养性B族维生素联合使用,可作为单一疗法或联合疗法来控制DPN症状。联合疗法可能具有协同作用并提高患者依从性。将结合常规实践和国家要求进一步考虑该共识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/10851824/f228a21e0d6d/JPPP_A_2306866_F0001_OC.jpg

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