Center for Advanced Systems Understanding (CASUS), Görlitz, Germany.
Helmholtz-Zentrum Dresden-Rossendorf e. V. (HZDR), Dresden, Germany.
mSphere. 2024 Feb 28;9(2):e0059123. doi: 10.1128/msphere.00591-23. Epub 2024 Feb 9.
Machine learning and artificial intelligence (AI) are becoming more common in infection biology laboratories around the world. Yet, as they gain traction in research, novel frontiers arise. Novel artificial intelligence algorithms are capable of addressing advanced tasks like image generation and question answering. However, similar algorithms can prove useful in addressing advanced questions in infection biology like prediction of host-pathogen interactions or inferring virus protein conformations. Addressing such tasks requires large annotated data sets, which are often scarce in biomedical research. In this review, I bring together several successful examples where such tasks were addressed. I underline the importance of formulating novel AI tasks in infection biology accompanied by freely available benchmark data sets to address these tasks. Furthermore, I discuss the current state of the field and potential future trends. I argue that one such trend involves AI tools becoming more versatile.
机器学习和人工智能(AI)在全球各地的感染生物学实验室中越来越常见。然而,随着它们在研究中的应用越来越广泛,新的前沿问题也随之出现。新型人工智能算法能够解决图像生成和问答等高级任务。然而,类似的算法在解决感染生物学中的高级问题方面也可能很有用,例如预测宿主-病原体相互作用或推断病毒蛋白构象。解决这些任务需要大型标注数据集,而这些数据集在生物医学研究中往往很缺乏。在这篇综述中,我汇集了几个成功的例子,这些例子解决了这些任务。我强调了在感染生物学中提出新的 AI 任务的重要性,并配有免费的基准数据集来解决这些任务。此外,我还讨论了该领域的现状和潜在的未来趋势。我认为,其中一个趋势是 AI 工具变得更加通用。