Doillon C J, Dunn M G, Bender E, Silver F H
Coll Relat Res. 1985 Dec;5(6):481-92. doi: 10.1016/s0174-173x(85)80002-9.
Dermal repair tissue shows a progressive increase in collagen content which may be related to the wound tensile strength. Wound strength and extensibility are lower than those found in normal skin. In animals, wounds closed by metal clips are chosen as a model to study the proliferative and remodeling phases of healing from a mechanical and morphological point of view. During the proliferative phase the low wound strength is associated with formation of collagen fibers of small diameter, later, (days 28-45) an acute change appears corresponding to the remodeling phase, with increased collagen fiber diameters observed by scanning electron microscopy and light microscopy, and increased tensile strength and toughness. By 180 days, wound strength and collagen fiber morphology were close to that observed in the normal skin. These observations show a direct relationship between collagen fiber diameter and tensile strength. In addition, packing density of collagen fibrils (determined by the birefringence retardation per unit thickness under polarized light) was unchanged until day 90, although collagen fiber diameters increased during this time.
真皮修复组织中的胶原蛋白含量呈逐渐增加的趋势，这可能与伤口的抗张强度有关。伤口的强度和延展性低于正常皮肤。在动物实验中，选用金属夹闭合的伤口作为模型，从力学和形态学角度研究愈合的增殖期和重塑期。在增殖期，伤口强度较低与小直径胶原纤维的形成有关，随后（第28 - 45天）出现对应于重塑期的急性变化，通过扫描电子显微镜和光学显微镜观察到胶原纤维直径增加，抗张强度和韧性也增加。到180天时，伤口强度和胶原纤维形态接近正常皮肤。这些观察结果表明胶原纤维直径与抗张强度之间存在直接关系。此外，胶原原纤维的堆积密度（通过偏振光下单位厚度的双折射延迟确定）在第90天之前保持不变，尽管在此期间胶原纤维直径增加。
