Roux Anne-Emmanuelle, Langella Philippe, Martin Rebeca
Paris-Saclay University, INRAE, AgroParisTech, Micalis Institute, 78350 Jouy-en-Josas, France.
Curr Opin Biotechnol. 2024 Apr;86:103073. doi: 10.1016/j.copbio.2024.103073. Epub 2024 Feb 9.
Although probiotics have been used in food products and supplements for decades, there has been a considerable increase in their use more recently. Recent technological advances have thus led to major advances in knowledge of the gut microbiota, enabling a significant development of biotics. In this review, we discuss the uses of traditional probiotics but also the discovery of next-generation probiotics that could be used as live biotherapeutics. These novel preventive and therapeutic strategies hold promise for the treatment of numerous diseases such as inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. Probiotic bacteria can be consumed alone, or in combination with prebiotics as synbiotics, or mixed with other probiotic strains to form a consortium for enhanced effects. We also discuss the benefits of using postbiotics.
尽管益生菌已在食品和补充剂中使用了数十年，但最近其使用量有了显著增加。因此，最近的技术进步带来了肠道微生物群知识的重大进展，推动了生物制剂的显著发展。在本综述中，我们不仅讨论了传统益生菌的用途，还探讨了可作为活体生物治疗剂使用的下一代益生菌的发现。这些新颖的预防和治疗策略有望用于治疗多种疾病，如克罗恩病和溃疡性结肠炎等炎症性肠病。益生菌可以单独食用，或与益生元组合作为合生元食用，或与其他益生菌菌株混合形成具有增强效果的联合体。我们还讨论了使用后生元的益处。
