Miao Changhong, Xu Xinyi, Huang Shuoxuan, Kong Lingyi, He Zhiwei, Wang Yihan, Chen Kuang, Xiao Lu
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China; Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
Hellenic J Cardiol. 2025 May-Jun;83:38-50. doi: 10.1016/j.hjc.2024.02.002. Epub 2024 Feb 8.
Recent studies have highlighted a connection between gut microbiota and hypertension, yet the precise nature of this relationship remains unclear.
This research aims to analyze the causal link between gut microbiota and hypertension, along with associated complications, utilizing two-sample bidirectional Mendelian randomization (MR).
Summary data from genome-wide association studies (GWAS) meta-analyses, including gut microbiota GWAS data from 24 cohorts, and the latest GWAS data for hypertension-related conditions were acquired. Employing various MR methods, including Inverse-variance weighted (IVW), MR-Egger, Weighted Median, Simple Mode, and Weighted Mode, we investigated the association between gut microbiota and hypertension-related conditions. Sensitivity analyses were conducted for result stability, and reverse MR analysis assessed the potential for reverse causality.
The Mendelian randomization analysis involving 199 microbial taxa and four phenotypes identified 46 microbial taxa with potential causal links to hypertension and its complications. Following Bonferroni correction, genus.Victivallis showed a robust causal relationship with hypertension (OR = 1.08, 95% CI = 1.04-1.12, P = 9.82e-5). This suggests an 8% increased risk of hypertension with each unit rise in genus.Victivallis abundance.
In conclusion, this study establishes a causal connection between gut microbiota and hypertension, along with common associated complications. The findings unveil potential targets and evidence for future hypertension and complication treatment through gut microbiota interventions, offering a novel avenue for therapeutic exploration.
近期研究强调了肠道微生物群与高血压之间的联系，但这种关系的确切性质仍不清楚。
本研究旨在利用两样本双向孟德尔随机化（MR）分析肠道微生物群与高血压及其相关并发症之间的因果关系。
获取全基因组关联研究（GWAS）荟萃分析的汇总数据，包括来自24个队列的肠道微生物群GWAS数据以及高血压相关疾病的最新GWAS数据。采用多种MR方法，包括逆方差加权（IVW）、MR-Egger、加权中位数、简单模式和加权模式，我们研究了肠道微生物群与高血压相关疾病之间的关联。进行敏感性分析以评估结果的稳定性，反向MR分析评估反向因果关系的可能性。
涉及199个微生物分类群和四种表型的孟德尔随机化分析确定了46个与高血压及其并发症有潜在因果关系的微生物分类群。经过Bonferroni校正后，Victivallis属与高血压显示出强烈的因果关系（OR = 1.08，95%CI = 1.04-1.12，P = 9.82e-5）。这表明Victivallis属丰度每增加一个单位，患高血压的风险增加8%。
总之，本研究建立了肠道微生物群与高血压及其常见相关并发症之间的因果关系。研究结果揭示了通过肠道微生物群干预治疗未来高血压和并发症的潜在靶点和证据，为治疗探索提供了一条新途径。
