Bagińska Joanna, Kirejczyk Jan Krzysztof, Korzeniecka-Kozerska Agata
Department of Pediatrics and Nephrology, Medical University of Białystok, 17 Waszyngtona Str., 15-274 Białystok, Poland.
Faculty of Health Sciences, University of Lomza, 14 Akademicka Str., 18-400 Lomza, Poland.
J Clin Med. 2024 Jan 27;13(3):736. doi: 10.3390/jcm13030736.
The article aims to find potential biomarker for the detection of tubular damage in pediatric neurogenic bladder (NB) by investigating urinary levels of liver-type fatty acid-binding protein (uL-FABP). This prospective analysis was conducted on two groups: 42 children with NB and 18 healthy children. The uL-FABP concentrations were measured using ELISA methods. The medical charts of the children were examined to determine age, sex, anthropometric measurements, activity assessment using Hoffer's scale, and renal function parameters. The results revealed that the uL-FABP/creatinine ratio was higher in the study group compared with the reference group, but the difference was not statistically significant ( = 0.52, > 0.05). However, the uL-FABP/creatinine ratio exhibited a wider range in NB patients compared to the reference group. NB children with proteinuria and the history of high-grade vesicoureteral reflux (VUR) tended to have the highest uL-FABP concentrations. In conclusion, uL-FABP may be considered a potential tubular damage biomarker in children with NB. Proteinuria and the history of VUR may be the factors influencing the uL-FABP.
本文旨在通过研究尿中肝型脂肪酸结合蛋白（uL-FABP）水平，寻找检测小儿神经源性膀胱（NB）肾小管损伤的潜在生物标志物。本前瞻性分析针对两组人群开展：42例NB患儿和18例健康儿童。采用酶联免疫吸附测定（ELISA）方法测量uL-FABP浓度。检查患儿的病历以确定年龄、性别、人体测量指标、使用霍弗量表进行的活动评估以及肾功能参数。结果显示，研究组的uL-FABP/肌酐比值高于参照组，但差异无统计学意义（=0.52，>0.05）。然而，与参照组相比，NB患者的uL-FABP/肌酐比值范围更广。有蛋白尿和高级别膀胱输尿管反流（VUR）病史的NB患儿uL-FABP浓度往往最高。总之，uL-FABP可被视为NB患儿潜在的肾小管损伤生物标志物。蛋白尿和VUR病史可能是影响uL-FABP的因素。
