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风险评分在未破裂前交通动脉瘤中的回顾性应用

Retrospective Application of Risk Scores to Unruptured Anterior Communicating Artery Aneurysms.

作者信息

Wójtowicz Katarzyna, Przepiorka Lukasz, Kujawski Sławomir, Maj Edyta, Marchel Andrzej, Kunert Przemysław

机构信息

Department of Neurosurgery, Medical University of Warsaw, 02-097 Warsaw, Poland.

Department of Exercise Physiology and Functional Anatomy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-077 Bydgoszcz, Poland.

出版信息

J Clin Med. 2024 Jan 30;13(3):789. doi: 10.3390/jcm13030789.

Abstract

BACKGROUND

Treatment decisions for unruptured intracranial aneurysms (UIAs) pose a challenge for neurosurgeons, prompting the development of clinical scales assessing hemorrhage risk to provide management guidance. This study compares recommendations from the PHASES and UIA treatment scores (UIATS) applied to anterior communicating artery (AComA) UIAs against real-world management.

METHODS

While UIATS recommends management, for PHASES, an aneurysm with score of 10 or more was considered "high-risk". Analysis involved assessing the concordance in each group alongside comparison to real-word management.

RESULTS

Among 129 patients, 46.5% were observed and 53.5% were treated. PHASES scores were significantly higher in the treatment group ( = 0.00002), and UIATS recommendations correlated with real-world decisions ( < 0.001). We observed no difference in the frequencies of UIATS recommendations between high- and low-risk groups. When comparing the UIATS and PHASES, 33% of high-risk aneurysms received a UIATS conservative management recommendation. In 39% of high-risk aneurysms, the UIATS recommendation was not definitive. Conversely, 27% of low-risk aneurysms obtained a UIATS UIA repair recommendation. Overall, concordance between PHASES and UIATS was 32%.

CONCLUSIONS

Significant discordance in therapeutic suggestions underscores the predominant influence of center experience and individual assessments. Future studies should refine and validate decision-making strategies, potentially exploring alternative applications or developing tailored scales.

摘要

背景

未破裂颅内动脉瘤(UIA)的治疗决策对神经外科医生而言是一项挑战,这促使了评估出血风险的临床量表的发展,以提供管理指导。本研究比较了应用于前交通动脉(AComA)UIA的PHASES和UIA治疗评分(UIATS)的建议与实际临床管理情况。

方法

虽然UIATS推荐了管理方式,但对于PHASES,得分10分及以上的动脉瘤被视为“高风险”。分析包括评估每组的一致性,并与实际临床管理情况进行比较。

结果

在129例患者中,46.5%接受观察,53.5%接受治疗。治疗组的PHASES评分显著更高(=0.00002),且UIATS建议与实际临床决策相关(<0.001)。我们观察到高风险组和低风险组之间UIATS建议的频率没有差异。比较UIATS和PHASES时,33%的高风险动脉瘤获得了UIATS保守管理建议。在39%的高风险动脉瘤中,UIATS的建议不明确。相反,27%的低风险动脉瘤获得了UIATS的UIA修复建议。总体而言,PHASES和UIATS之间的一致性为32%。

结论

治疗建议中的显著不一致突出了中心经验和个体评估的主要影响。未来的研究应完善和验证决策策略,可能探索替代应用或制定定制量表。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf0b/10856240/88536b00ed0b/jcm-13-00789-g001.jpg

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