Ionică Mihaela, Biris Marius, Gorun Florin, Nicolae Nicoleta, Popa Zoran Laurentiu, Muresan Maria Cezara, Forga Marius, Erdelean Dragos, Erdelean Izabella, Gorun Mihai Adrian, Neagoe Octavian Constantin
Second Clinic of General Surgery and Surgical Oncology, Emergency Clinical Municipal Hospital, 300079 Timisoara, Romania.
Second Discipline of Surgical Semiology, First Department of Surgery, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
J Clin Med. 2024 Jan 30;13(3):794. doi: 10.3390/jcm13030794.
This study aims to investigate the association between anemia and early recurrence in endometrial cancer patients. We retrospectively analyzed the data of 473 endometrial cancer patients treated at our hospital from January 2015 to December 2020. Patients were divided into two groups based on their hemoglobin (Hb) level: anemia group (Hb < 12 g/dL) and non-anemia group (Hb ≥12 g/dL). Early recurrence was defined as recurrence within 2 years of diagnosis. Univariate and multivariate logistic regression analyses were used to identify the predictors of early recurrence. The prevalence of anemia was 38.26% (181/473). The incidence of early recurrence was 12.89% (61/473) in the anemia group and 9.24% (38/412) in the non-anemia group ( = 0.004). Univariate analysis showed that anemia was a significant predictor of early recurrence (odds ratio (OR) = 2.27, 95% confidence interval (CI): 1.35-3.80, = 0.003). Multivariate analysis confirmed that anemia was an independent predictor of early recurrence (OR = 2.11, 95% CI: 1.21-3.84, = 0.01). Anemia is an independent predictor of early recurrence in endometrial cancer patients. Patients with endometrial cancer should be screened for anemia and treated if present. Additionally, patients with anemia should be closely monitored for early signs of recurrence and treated aggressively.
本研究旨在探讨子宫内膜癌患者贫血与早期复发之间的关联。我们回顾性分析了2015年1月至2020年12月在我院接受治疗的473例子宫内膜癌患者的数据。根据血红蛋白（Hb）水平将患者分为两组：贫血组（Hb < 12 g/dL）和非贫血组（Hb≥12 g/dL）。早期复发定义为诊断后2年内复发。采用单因素和多因素逻辑回归分析来确定早期复发的预测因素。贫血的患病率为38.26%（181/473）。贫血组的早期复发率为12.89%（61/473），非贫血组为9.24%（38/412）（P = 0.004）。单因素分析显示，贫血是早期复发的显著预测因素（优势比（OR） = 2.27，95%置信区间（CI）：1.35 - 3.80，P = 0.003）。多因素分析证实，贫血是早期复发的独立预测因素（OR = 2.11，95% CI：1.21 - 3.84，P = 0.01）。贫血是子宫内膜癌患者早期复发的独立预测因素。子宫内膜癌患者应进行贫血筛查，如有贫血应进行治疗。此外，贫血患者应密切监测复发的早期迹象并积极治疗。
