Pediatrics and Neonatology Unit, University of Parma, Gugliemo da Saliceto Hospital, 29121 Piacenza, Italy.
Department of Medicine and Surgery, University of Parma, 43121 Parma, Italy.
Nutrients. 2024 Jan 31;16(3):416. doi: 10.3390/nu16030416.
The definition of "Vitamin D" encompasses a group of fat-soluble steroid compounds of different origins with similar chemical structures and the same biological effects. Vitamin D deficiency and/or a defect in the process of its synthesis or transport predispose individuals to several types of rickets. In addition to cholecalciferol, ergocalciferol, and vitamins D3 and D2, there are also active metabolites for the treatment of this condition which are commercially available. Calcitriol and aphacalcidiol are active metabolites that do not require the renal activation step, which is required with calcifediol, or hepatic activation. The purpose of this review is to summarize current approaches to the treatment of rickets for generalist physicians, focusing on the best vitamin D form to be used in each type, or, in the case of X-linked hypophosphatemic rickets (XLH), on both conventional and innovative monoclonal antibody treatments.
“维生素 D”的定义包括一组不同来源的脂溶性甾体化合物，它们具有相似的化学结构和相同的生物学效应。维生素 D 缺乏和/或其合成或运输过程中的缺陷使个体易患多种佝偻病。除胆钙化醇、麦角钙化醇、维生素 D3 和 D2 外，还有用于治疗这种疾病的活性代谢物可供商业使用。骨化三醇和阿法骨化二醇是不需要肾激活步骤的活性代谢物，而Calcifediol 需要肾激活步骤，或肝激活步骤。本综述的目的是为全科医生总结佝偻病的治疗方法，重点是每种类型使用的最佳维生素 D 形式，或者在 X 连锁低磷血症性佝偻病 (XLH) 的情况下，同时讨论传统和创新的单克隆抗体治疗。
