多孔有机材料在组织工程中的应用:用于修复面神经损伤的最新进展和应用

Porous Organic Materials in Tissue Engineering: Recent Advances and Applications for Severed Facial Nerve Injury Repair.

机构信息

The First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin Medical University, Harbin 150001, China.

National Key Laboratory of Science and Technology on Advanced Composites in Special Environments, Harbin Institute of Technology, Harbin 150080, China.

出版信息

Molecules. 2024 Jan 23;29(3):566. doi: 10.3390/molecules29030566.

Abstract

The prevalence of facial nerve injury is substantial, and the restoration of its structure and function remains a significant challenge. Autologous nerve transplantation is a common treatment for severed facial nerve injury; however, it has great limitations. Therefore, there is an urgent need for clinical repair methods that can rival it. Tissue engineering nerve conduits are usually composed of scaffolds, cells and neurofactors. Tissue engineering is regarded as a promising method for facial nerve regeneration. Among different factors, the porous nerve conduit made of organic materials, which has high porosity and biocompatibility, plays an indispensable role. This review introduces facial nerve injury and the existing treatment methods and discusses the necessity of the application of porous nerve conduit. We focus on the application of porous organic polymer materials from production technology and material classification and summarize the necessity and research progress of these in repairing severed facial nerve injury, which is relatively rare in the existing articles. This review provides a theoretical basis for further research into and clinical interventions on facial nerve injury and has certain guiding significance for the development of new materials.

摘要

面神经损伤的发病率相当高,其结构和功能的恢复仍然是一个重大挑战。自体神经移植是治疗面神经完全断裂的常用方法,但存在很大的局限性。因此,迫切需要能够与之相媲美的临床修复方法。组织工程神经导管通常由支架、细胞和神经营养因子组成。组织工程被认为是面神经再生的一种很有前途的方法。在不同的因素中,由有机材料制成的多孔神经导管具有高孔隙率和生物相容性,起着不可或缺的作用。本文介绍了面神经损伤及其现有的治疗方法,并讨论了应用多孔神经导管的必要性。我们专注于从生产技术和材料分类的角度介绍多孔有机聚合物材料的应用,并总结了这些材料在修复面神经完全断裂中的必要性和研究进展,这在现有文献中相对较少。本文为面神经损伤的进一步研究和临床干预提供了理论基础,对新材料的开发具有一定的指导意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5499/10856494/d97c0d6b150c/molecules-29-00566-g001.jpg

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