Wang Yiyu, Wang Zhengke, Dong Yan
Department of Prosthodontics, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310029, China.
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
ACS Biomater Sci Eng. 2023 Mar 13;9(3):1132-1150. doi: 10.1021/acsbiomaterials.2c00730. Epub 2023 Feb 17.
Collagen is commonly used as a regenerative biomaterial due to its excellent biocompatibility and wide distribution in tissues. Different kinds of hybridization or cross-links are favored to offer improvements to satisfy various needs of biomedical applications. Previous reviews have been made to introduce the sources and structures of collagen. In addition, biological and mechanical properties of collagen-based biomaterials, their modification and application forms, and their interactions with host tissues are pinpointed. However, there is still no review about collagen-based biomaterials for tissue engineering. Therefore, we aim to summarize and discuss the progress of collagen-based materials for tissue regeneration applications in this review. We focus on the utilization of collagen-based biomaterials for bones, cartilages, skin, dental, neuron, cornea, and urological applications and hope these experiences and outcomes can provide inspiration and practical techniques for the future development of collagen-based biomaterials in related application fields. Moreover, future improving directions and challenges for collagen-based biomaterials are proposed as well.
胶原蛋白因其优异的生物相容性和在组织中的广泛分布，常被用作再生生物材料。人们倾向于采用不同种类的杂交或交联方法来进行改进，以满足生物医学应用的各种需求。此前已有综述介绍了胶原蛋白的来源和结构。此外，还指出了基于胶原蛋白的生物材料的生物学和力学性能、它们的改性和应用形式，以及它们与宿主组织的相互作用。然而，目前仍没有关于用于组织工程的基于胶原蛋白的生物材料的综述。因此，我们旨在在本综述中总结和讨论用于组织再生应用的基于胶原蛋白的材料的进展。我们重点关注基于胶原蛋白的生物材料在骨骼、软骨、皮肤、牙科、神经元、角膜和泌尿系统应用中的利用情况，并希望这些经验和成果能够为基于胶原蛋白的生物材料在相关应用领域的未来发展提供灵感和实用技术。此外，还提出了基于胶原蛋白的生物材料未来的改进方向和挑战。
