College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.
Int J Mol Sci. 2024 Jan 24;25(3):1429. doi: 10.3390/ijms25031429.
Acute colitis is a complex disease that can lead to dysregulation of the gut flora, inducing more complex parenteral diseases. Dandelion polysaccharides (DPSs) may have potential preventive and therapeutic effects on enteritis. In this study, LPS was used to induce enteritis and VC was used as a positive drug control to explore the preventive and therapeutic effects of DPS on enteritis. The results showed that DPS could repair the intestinal barrier, down-regulate the expression of TNF-α, IL-6, IL-1β, and other pro-inflammatory factors, up-regulate the expression of IL-22 anti-inflammatory factor, improve the antioxidant capacity of the body, and improve the structure of intestinal flora. It is proved that DPS can effectively prevent and treat LPS-induced acute enteritis and play a positive role in promoting intestinal health.
急性结肠炎是一种复杂的疾病，可导致肠道菌群失调，诱发更复杂的肠外疾病。蒲公英多糖（DPS）可能对肠炎具有潜在的预防和治疗作用。本研究采用 LPS 诱导肠炎，以 VC 作为阳性药物对照，探讨 DPS 对肠炎的预防和治疗作用。结果表明，DPS 可修复肠道屏障，下调 TNF-α、IL-6、IL-1β 等促炎因子的表达，上调 IL-22 抗炎因子的表达，提高机体抗氧化能力，改善肠道菌群结构。证明 DPS 能有效防治 LPS 诱导的急性肠炎，对促进肠道健康发挥积极作用。
