Department of Physiology and Convergence Medical Science, Institute of Medical Science, College of Medicine, Gyeongsang National University, Jinju 52727, Republic of Korea.
Department of Microbiology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
Int J Mol Sci. 2024 Jan 29;25(3):1638. doi: 10.3390/ijms25031638.
Viruses have evolved sophisticated mechanisms to manipulate host cell processes and utilize intracellular organelles to facilitate their replication. These complex interactions between viruses and cellular organelles allow them to hijack the cellular machinery and impair homeostasis. Moreover, viral infection alters the cell membrane's structure and composition and induces vesicle formation to facilitate intracellular trafficking of viral components. However, the research focus has predominantly been on the immune response elicited by viruses, often overlooking the significant alterations that viruses induce in cellular organelles. Gaining a deeper understanding of these virus-induced cellular changes is crucial for elucidating the full life cycle of viruses and developing potent antiviral therapies. Exploring virus-induced cellular changes could substantially improve our understanding of viral infection mechanisms.
病毒已经进化出了复杂的机制来操纵宿主细胞的过程，并利用细胞内的细胞器来促进它们的复制。这些病毒和细胞细胞器之间的复杂相互作用使它们能够劫持细胞机制并破坏内稳态。此外，病毒感染改变细胞膜的结构和组成，并诱导囊泡形成，以促进病毒成分的细胞内运输。然而，研究的重点主要集中在病毒引起的免疫反应上，往往忽略了病毒对细胞细胞器引起的重大改变。深入了解这些病毒引起的细胞变化对于阐明病毒的完整生命周期和开发有效的抗病毒疗法至关重要。探索病毒引起的细胞变化可以大大提高我们对病毒感染机制的理解。
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