Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital, Capital Medical University, Beijing, China.
Front Immunol. 2023 Mar 30;14:1154217. doi: 10.3389/fimmu.2023.1154217. eCollection 2023.
Exosomes are messengers of intercellular communication in monolayer vesicles derived from cells. It affects the pathophysiological process of the body in various diseases, such as tumors, inflammation, and infection. It has been confirmed that exosomes are similar to viruses in biogenesis, and exosome cargo is widely involved in many viruses' replication, transmission, and infection. Simultaneously, virus-associated exosomes can promote immune escape and activate the antiviral immune response of the body, which bidirectionally modulates the immune response. This review focuses on the role of exosomes in HIV, HBV, HCV, and SARS-CoV-2 infection and explores the prospects of exosome development. These insights may be translated into therapeutic measures for viral infections and reduce the disease burden.
外泌体是源自细胞的单层小泡中的细胞间通讯信使。它在各种疾病（如肿瘤、炎症和感染）的病理生理过程中发挥作用。已经证实，外泌体在生物发生上类似于病毒，并且外泌体货物广泛涉及许多病毒的复制、传播和感染。同时，病毒相关的外泌体可以促进免疫逃逸并激活机体的抗病毒免疫反应，从而双向调节免疫反应。本综述重点介绍了外泌体在 HIV、HBV、HCV 和 SARS-CoV-2 感染中的作用，并探讨了外泌体开发的前景。这些见解可能转化为病毒感染的治疗措施，从而减轻疾病负担。
