Department of Biochemistry and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, Republic of Korea.
Int J Mol Sci. 2023 Feb 8;24(4):3423. doi: 10.3390/ijms24043423.
Viruses must cross the plasma membrane to infect cells, making them eager to overcome this barrier in order to replicate in hosts. They bind to cell surface receptors as the first step of initiating entry. Viruses can use several surface molecules that allow them to evade defense mechanisms. Various mechanisms are stimulated to defend against viruses upon their entry into cells. Autophagy, one of the defense systems, degrades cellular components to maintain homeostasis. The presence of viruses in the cytosol regulates autophagy; however, the mechanisms by which viral binding to receptors regulates autophagy have not yet been fully established. This review discusses recent findings on autophagy induced by interactions between viruses and receptors. It provides novel perspectives on the mechanism of autophagy as regulated by viruses.
病毒必须穿过质膜才能感染细胞，这使得它们急于克服这一障碍，以便在宿主体内复制。它们作为进入的第一步与细胞表面受体结合。病毒可以利用几种表面分子来逃避防御机制。各种机制被刺激以抵御进入细胞的病毒。自噬是防御系统之一，可降解细胞成分以维持体内平衡。病毒在细胞质中的存在调节自噬；然而，病毒与受体结合调节自噬的机制尚未完全建立。本文综述了病毒与受体相互作用诱导自噬的最新发现。它为病毒调节自噬的机制提供了新的视角。
