Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
China National Clinical Research Center for Neurological Diseases, Beijing, China.
Hum Brain Mapp. 2024 Feb 1;45(2):e26583. doi: 10.1002/hbm.26583.
Although it has been established that cross-modal activations occur in the occipital cortex during auditory processing among congenitally and early blind listeners, it remains uncertain whether these activations in various occipital regions reflect sensory analysis of specific sound properties, non-perceptual cognitive operations associated with active tasks, or the interplay between sensory analysis and cognitive operations. This fMRI study aimed to investigate cross-modal responses in occipital regions, specifically V5/MT and V1, during passive and active pitch perception by early blind individuals compared to sighted individuals. The data showed that V5/MT was responsive to pitch during passive perception, and its activations increased with task complexity. By contrast, widespread occipital regions, including V1, were only recruited during two active perception tasks, and their activations were also modulated by task complexity. These fMRI results from blind individuals suggest that while V5/MT activations are both stimulus-responsive and task-modulated, activations in other occipital regions, including V1, are dependent on the task, indicating similarities and differences between various visual areas during auditory processing.
虽然已经证实，在先天性和早期失明者的听觉处理过程中，枕叶皮层会发生跨模态激活，但目前尚不清楚各种枕叶区域的这些激活是反映特定声音属性的感觉分析、与主动任务相关的非知觉认知操作，还是感觉分析和认知操作之间的相互作用。这项 fMRI 研究旨在调查早期失明者和视力正常者在被动和主动感知音高时，枕叶区域（特别是 V5/MT 和 V1）的跨模态反应。数据显示，V5/MT 在被动感知时对音高有反应，其激活随着任务复杂性的增加而增加。相比之下，广泛的枕叶区域，包括 V1，仅在两个主动感知任务中被招募，它们的激活也受到任务复杂性的调节。这些来自失明者的 fMRI 结果表明，虽然 V5/MT 的激活既是刺激反应又是任务调节的，但包括 V1 在内的其他枕叶区域的激活依赖于任务，这表明在听觉处理过程中各种视觉区域之间存在相似性和差异性。
