Ross John Paul, Post Stephen G, Scheinfeld Laurel
Department of Family, Population and Preventive Medicine, Center for Medical Humanities, Compassionate Care and Bioethics, Renaissance School of Medicine at SUNY Stony Brook, Stony Brook, NY, USA.
Health Sciences Library, SUNY Stony Brook, Stony Brook, NY, USA.
J Alzheimers Dis. 2024;98(1):3-11. doi: 10.3233/JAD-231396.
Even in severe states of Alzheimer's disease and related dementias (ADRD), accounts of an unexpected or paradoxical return of awareness and lucidity have been reported in some patients, documented formally, and studied.
A scoping review was undertaken to survey the literature on the topic.
Five databases were searched using pertinent search terms. Results were deduplicated and subsequently screened by title and abstract for relevance. Remaining reports were read and included or excluded using specific inclusion criteria. 30 results consisted of a mix of perspective papers, case reports, qualitative surveys of caregivers, law journal comments, and mechanistic speculation.
An equal mix of primary and secondary research was identified.
The papers collected in this review provide a valuable methodological outline for researching the topic of lucid episodes in ADRD. The verified legitimacy and simultaneous inexplicability of these events promote philosophical discussion, mechanistic investigations, and sorely needed research in the field of ADRD.
即使在阿尔茨海默病及相关痴呆症（ADRD）的严重阶段，仍有报道称部分患者出现了意识和清醒状态意外或矛盾性恢复的情况，这些情况有正式记录并得到了研究。
进行一项范围综述以调查该主题的文献。
使用相关检索词对五个数据库进行检索。对结果进行去重，随后通过标题和摘要筛选相关性。阅读剩余报告，并根据特定纳入标准决定是否纳入。30项结果包括观点论文、病例报告、对护理人员的定性调查、法律期刊评论以及机制推测。
确定了初级研究和次级研究的均衡组合。
本综述收集的论文为研究ADRD中清醒发作这一主题提供了有价值的方法概述。这些事件已证实的合理性与同时存在的无法解释性引发了哲学讨论、机制研究以及ADRD领域急需的研究。
