McKenzie Andrew T, Wowk Brian, Arkhipov Anton, Wróbel Borys, Cheng Nathan, Kendziorra Emil F
Apex Neuroscience, Salem, OR 97317, USA.
21st Century Medicine, Inc., Fontana, CA 92336, USA.
Brain Sci. 2024 Sep 21;14(9):942. doi: 10.3390/brainsci14090942.
Human biostasis, the preservation of a human when all other contemporary options for extension of quality life are exhausted, offers the speculative potential for survival via continuation of life in the future. While provably reversible preservation, also known as suspended animation, is not yet possible for humans, the primary justification for contemporary biostasis is the preservation of the brain, which is broadly considered the seat of memories, personality, and identity. By preserving the information contained within the brain's structures, it may be possible to resuscitate a healthy whole individual using advanced future technologies. There are numerous challenges in biostasis, including inadequacies in current preservation techniques, methods to evaluate the quality of preservation, and potential future revival technologies. In this report, we describe a roadmap that attempts to delineate research directions that could improve the field of biostasis, focusing on optimizing preservation protocols and establishing metrics for querying preservation quality, as well as pre- and post-cardiac arrest factors, stabilization strategies, and methods for long-term preservation. We acknowledge the highly theoretical nature of future revival technologies and the importance of achieving high-fidelity brain preservation to maximize the potential of future repair technologies. We plan to update the research roadmap biennially. Our goal is to encourage multidisciplinary communication and collaboration in this field.
人体生物静止状态，即在所有其他延长优质生活的当代选择都已穷尽时对人体进行保存，为未来通过延续生命实现生存提供了一种推测性的可能性。虽然对人类来说，可证明的可逆保存，即所谓的假死状态，目前还无法实现，但当代生物静止状态的主要理由是保存大脑，大脑被广泛认为是记忆、个性和身份的所在。通过保存大脑结构中包含的信息，利用未来先进技术有可能复苏一个健康的完整个体。生物静止状态存在诸多挑战，包括当前保存技术的不足、评估保存质量的方法以及潜在的未来复苏技术。在本报告中，我们描述了一个路线图，试图勾勒出可改善生物静止状态领域的研究方向，重点是优化保存方案、建立用于查询保存质量的指标，以及心脏骤停前后的因素、稳定策略和长期保存方法。我们认识到未来复苏技术具有高度的理论性，以及实现高保真大脑保存对于最大化未来修复技术潜力的重要性。我们计划每两年更新一次研究路线图。我们的目标是鼓励该领域的多学科交流与合作。
