利用从规范模型中进行的迁移学习来估计不同扫描仪中儿童的皮质厚度轨迹。
Estimating cortical thickness trajectories in children across different scanners using transfer learning from normative models.
机构信息
Department of Neuroscience, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
The Generation R Study Group, Erasmus MC-Sophia Children's Hospital, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
出版信息
Hum Brain Mapp. 2024 Feb 1;45(2):e26565. doi: 10.1002/hbm.26565.
This work illustrates the use of normative models in a longitudinal neuroimaging study of children aged 6-17 years and demonstrates how such models can be used to make meaningful comparisons in longitudinal studies, even when individuals are scanned with different scanners across successive study waves. More specifically, we first estimated a large-scale reference normative model using Hierarchical Bayesian Regression from N = 42,993 individuals across the lifespan and from dozens of sites. We then transfer these models to a longitudinal developmental cohort (N = 6285) with three measurement waves acquired on two different scanners that were unseen during estimation of the reference models. We show that the use of normative models provides individual deviation scores that are independent of scanner effects and efficiently accommodate inter-site variations. Moreover, we provide empirical evidence to guide the optimization of sample size for the transfer of prior knowledge about the distribution of regional cortical thicknesses. We show that a transfer set containing as few as 25 samples per site can lead to good performance metrics on the test set. Finally, we demonstrate the clinical utility of this approach by showing that deviation scores obtained from the transferred normative models are able to detect and chart morphological heterogeneity in individuals born preterm.
本研究展示了规范模型在儿童纵向神经影像学研究中的应用,并证明了即使个体在连续的研究波次中使用不同的扫描仪进行扫描,这些模型也可以用于在纵向研究中进行有意义的比较。具体来说,我们首先使用分层贝叶斯回归,从跨越整个生命周期的 N=42993 个人和数十个站点中估计了一个大规模的参考规范模型。然后,我们将这些模型转移到一个具有三个测量波次的纵向发展队列中(N=6285),这些波次是在参考模型估计期间使用两种不同的扫描仪进行的,这些扫描仪在参考模型的估计过程中并未被观察到。我们表明,使用规范模型可以提供独立于扫描仪效应的个体偏差分数,并有效地适应站点间的差异。此外,我们提供了经验证据来指导关于区域皮质厚度分布的先验知识转移的样本量优化。我们表明,转移集每个站点包含多达 25 个样本就可以在测试集上获得良好的性能指标。最后,我们通过展示从转移规范模型中获得的偏差分数能够检测和描绘早产儿个体的形态异质性,证明了这种方法的临床实用性。