Sugimoto Y
Nihon Seikeigeka Gakkai Zasshi. 1985 Dec;59(12):1059-72.
The healing process of osteochondral fracture was studied experimentally and clinically, using fibrin adhesive system (FAS) containing highly concentrated and freeze-dried fibrinogen, thrombin and factor XIII. Osteochondral fractures were made in the femoral condyle of the rabbit. Most of the adhered fibrin was gradually absorbed at the fracture site and at the same time was replaced with granulation tissue containing abundant capillaries, fibroblasts and osteoblasts, by the 10th day. Complete fracture healing was achieved histologically in one month. Fifteen cases of intraarticular osteochondral fractures in the hand were treated with FAS clinically. Complete bony union was obtained in all cases at 3 to 6 weeks postoperatively. The range of motion was limited in 3 cases, but was excellent in the other 12 cases. From our experimental and clinical results, it appears that FAS may produce no obstructive effects in bony healing. Management of intraarticular osteochondral fixation would be much easier by using FAS than by the conventional fixation materials such as metal screws or K-wire.
利用含有高浓度冻干纤维蛋白原、凝血酶和 XIII 因子的纤维蛋白黏附系统（FAS），对骨软骨骨折的愈合过程进行了实验和临床研究。在兔股骨髁制造骨软骨骨折。到第10天时，大部分黏附的纤维蛋白在骨折部位逐渐被吸收，同时被含有丰富毛细血管、成纤维细胞和成骨细胞的肉芽组织所替代。组织学上在1个月时实现了骨折的完全愈合。临床上对15例手部关节内骨软骨骨折患者使用FAS进行治疗。所有病例术后3至6周均实现了完全骨愈合。3例患者的活动范围受限，但其他12例患者情况良好。从我们的实验和临床结果来看，FAS似乎对骨愈合没有阻碍作用。与使用金属螺钉或克氏针等传统固定材料相比，使用FAS进行关节内骨软骨固定的操作要容易得多。
