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关于平均驻留时间测定的评论

Comments on mean residence time determination.

作者信息

Landaw E M, Katz D

出版信息

J Pharmacokinet Biopharm. 1985 Oct;13(5):543-7. doi: 10.1007/BF01059335.

DOI:10.1007/BF01059335
PMID:3834067
Abstract

In a recent paper, D. O. Chanter challenged the applicability of the use of statistical moments in estimating mean residence time and proposed an alternative approach. Errors in that paper are pointed out which involve the improper equating of whole-body amount of drug with plasma amount of drug in a kinetic system. The theory for the two methods discussed by Chanter is presented in a pharmacokinetic context.

摘要

在最近的一篇论文中,D.O. 钱特对使用统计矩来估计平均滞留时间的适用性提出了质疑,并提出了一种替代方法。文中指出了该论文中的错误,这些错误涉及在动力学系统中将体内药物总量与血浆药物量不恰当地等同起来。钱特所讨论的两种方法的理论是在药代动力学背景下呈现的。

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Some considerations on the estimation of steady state apparent volume of distribution and the relationships between volume terms.关于稳态表观分布容积估计及容积术语之间关系的一些思考
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