The relevance of residence time theory to pharmacokinetics.

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作者信息

Weiss M

机构信息

Department of Pharmacology and Toxicology, Martin Luther University Halle-Wittenberg, Halle/Saale, FRG.

出版信息

Eur J Clin Pharmacol. 1992;43(6):571-9. doi: 10.1007/BF02284953.

DOI:10.1007/BF02284953

PMID:1493836

Abstract

摘要

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The relevance of residence time theory to pharmacokinetics.

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本文引用的文献

Applications of a recirculatory stochastic pharmacokinetic model: limitations of compartmental models.循环随机药代动力学模型的应用：房室模型的局限性

J Pharmacokinet Biopharm. 1979 Apr;7(2):207-25. doi: 10.1007/BF01059739.

[A simple statistical dosage metabolism law].[一个简单的统计剂量代谢规律]

Klin Wochenschr. 1958 Jul 15;36(14):655-7. doi: 10.1007/BF01488743.

The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption time.统计矩理论在体内溶出时间和吸收时间评估中的应用。

J Pharmacokinet Biopharm. 1980 Oct;8(5):509-34. doi: 10.1007/BF01059549.

Residence time and accumulation of drugs in the body.

Int J Clin Pharmacol Ther Toxicol. 1981 Feb;19(2):82-5.

Moments of physiological transit time distributions and the time course of drug disposition in the body.生理转运时间分布的时刻以及药物在体内处置的时间进程。

J Math Biol. 1982;15(3):305-18. doi: 10.1007/BF00275690.

Noncompartmental determination of the steady-state volume of distribution for any mode of administration.非房室模型法测定任何给药方式下的稳态分布容积。

J Pharm Sci. 1982 Mar;71(3):372-3. doi: 10.1002/jps.2600710332.

Hemodynamic influences upon the variance of disposition residence time distribution of drugs.血流动力学对药物处置停留时间分布方差的影响。

J Pharmacokinet Biopharm. 1983 Feb;11(1):63-75. doi: 10.1007/BF01061768.

Statistical analysis of bioavailability studies: parametric and nonparametric confidence intervals.

Eur J Clin Pharmacol. 1983;24(1):127-36. doi: 10.1007/BF00613939.

Estimation of mean residence time from data obtained when multiple-dosing steady state has been reached.根据达到多剂量稳态时获得的数据估算平均驻留时间。

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Multiexponential, multicompartmental, and noncompartmental modeling. I. Methodological limitations and physiological interpretations.多指数、多房室和非房室建模。I. 方法学局限性及生理学解释。

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