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The relevance of residence time theory to pharmacokinetics.

作者信息

Weiss M

机构信息

Department of Pharmacology and Toxicology, Martin Luther University Halle-Wittenberg, Halle/Saale, FRG.

出版信息

Eur J Clin Pharmacol. 1992;43(6):571-9. doi: 10.1007/BF02284953.

DOI:10.1007/BF02284953
PMID:1493836
Abstract
摘要

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The relevance of residence time theory to pharmacokinetics.
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studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability.钙、多种维生素和牛奶对单剂量环丙沙星生物利用度的定量影响研究。
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本文引用的文献

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Applications of a recirculatory stochastic pharmacokinetic model: limitations of compartmental models.循环随机药代动力学模型的应用：房室模型的局限性
J Pharmacokinet Biopharm. 1979 Apr;7(2):207-25. doi: 10.1007/BF01059739.
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[A simple statistical dosage metabolism law].[一个简单的统计剂量代谢规律]
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The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption time.统计矩理论在体内溶出时间和吸收时间评估中的应用。
用于拟合有无静脉内参比情况下口服浓度-时间曲线的经验模型。
J Pharmacokinet Pharmacodyn. 2017 Jun;44(3):193-201. doi: 10.1007/s10928-017-9507-3. Epub 2017 Feb 1.
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In silico labeling reveals the time-dependent label half-life and transit-time in dynamical systems.计算机模拟标记揭示了动态系统中随时间变化的标记半衰期和转运时间。
BMC Syst Biol. 2012 Feb 27;6:13. doi: 10.1186/1752-0509-6-13.
5
How does obesity affect residence time dispersion and the shape of drug disposition curves? Thiopental as an example.肥胖如何影响 Residence time dispersion 和药物处置曲线的形状？以硫喷妥钠为例。 （注：“Residence time dispersion”直译为“停留时间分散”，在医学领域可能有更专业的术语表述，这里按原文翻译）
J Pharmacokinet Pharmacodyn. 2008 Jun;35(3):325-36. doi: 10.1007/s10928-008-9090-8. Epub 2008 May 9.
6
Residence time dispersion as a general measure of drug distribution kinetics: estimation and physiological interpretation.停留时间分布作为药物分布动力学的一般度量：估计与生理学解释。
Pharm Res. 2007 Nov;24(11):2025-30. doi: 10.1007/s11095-007-9332-2. Epub 2007 May 18.
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Pharmacokinetics and toxicity of idarubicin in the rat.伊达比星在大鼠体内的药代动力学及毒性
Eur J Drug Metab Pharmacokinet. 2001 Oct-Dec;26(4):215-9. doi: 10.1007/BF03226374.
8
Simultaneous fitting of R- and S-ibuprofen plasma concentrations after oral administration of the racemate.口服消旋体后R-和S-布洛芬血浆浓度的同步拟合。
Br J Clin Pharmacol. 2001 Oct;52(4):387-98. doi: 10.1046/j.1365-2125.2001.01451.x.
9
A novel extravascular input function for the assessment of drug absorption in bioavailability studies.一种用于生物利用度研究中评估药物吸收的新型血管外输入函数。
Pharm Res. 1996 Oct;13(10):1547-53. doi: 10.1023/a:1016039931663.
10
Tissue distribution kinetics as determinant of transit time dispersion of drugs in organs: application of a stochastic model to the rat hindlimb.作为药物在器官中转运时间弥散决定因素的组织分布动力学：随机模型在大鼠后肢的应用
J Pharmacokinet Biopharm. 1996 Apr;24(2):173-96. doi: 10.1007/BF02353488.
J Pharmacokinet Biopharm. 1980 Oct;8(5):509-34. doi: 10.1007/BF01059549.
4
Residence time and accumulation of drugs in the body.
Int J Clin Pharmacol Ther Toxicol. 1981 Feb;19(2):82-5.
5
Moments of physiological transit time distributions and the time course of drug disposition in the body.生理转运时间分布的时刻以及药物在体内处置的时间进程。
J Math Biol. 1982;15(3):305-18. doi: 10.1007/BF00275690.
6
Noncompartmental determination of the steady-state volume of distribution for any mode of administration.非房室模型法测定任何给药方式下的稳态分布容积。
J Pharm Sci. 1982 Mar;71(3):372-3. doi: 10.1002/jps.2600710332.
7
Hemodynamic influences upon the variance of disposition residence time distribution of drugs.血流动力学对药物处置停留时间分布方差的影响。
J Pharmacokinet Biopharm. 1983 Feb;11(1):63-75. doi: 10.1007/BF01061768.
8
Statistical analysis of bioavailability studies: parametric and nonparametric confidence intervals.
Eur J Clin Pharmacol. 1983;24(1):127-36. doi: 10.1007/BF00613939.
9
Estimation of mean residence time from data obtained when multiple-dosing steady state has been reached.根据达到多剂量稳态时获得的数据估算平均驻留时间。
J Pharm Sci. 1984 Jun;73(6):854-6. doi: 10.1002/jps.2600730645.
10
Multiexponential, multicompartmental, and noncompartmental modeling. I. Methodological limitations and physiological interpretations.多指数、多房室和非房室建模。I. 方法学局限性及生理学解释。
Am J Physiol. 1984 May;246(5 Pt 2):R651-64. doi: 10.1152/ajpregu.1984.246.5.R651.