Kasuya Y, Ohno T, Kubota N, Takahashi H, Hirayama H
J Pharmacokinet Biopharm. 1985 Dec;13(6):571-87. doi: 10.1007/BF01058902.
Variability in an individual's clearance of theophylline is an important consideration when estimating bioavailability. A method is described for compensating for this problem, using the serum concentration of theophylline and urinary excretion data on its major metabolites to make an estimation of the clearance after oral administration using the intravenous dose as reference. The method is particularly useful for assessing the bioavailability of slow-release theophylline preparations.
