哮喘儿童急性发作期与缓解期茶碱的药代动力学比较。

A comparison of the pharmacokinetics of theophylline in asthmatic children in the acute episode and in remission.

作者信息

Arnold J D, Hill G N, Sansom L N

出版信息

Eur J Clin Pharmacol. 1981;20(6):443-7. doi: 10.1007/BF00542097.

DOI:10.1007/BF00542097

Abstract

The pharmacokinetics of theophylline following a single intravenous dose of aminophylline were determined in 8 asthmatic patients in each of the acute, the recovery and the remission phase. The overall results for mean plasma theophylline clearance (78.6 +/- 33.3 ml/kg/h), plasma theophylline half-life (4.14 +/- 1.36 h) and apparent volume of distribution (0.41 +/- 0.066 l/kg) are in accordance with previously published values. There was no general statistically significant difference in any of the pharmacokinetic parameters when results from the acute and remission phases were compared. However, certain patients showed reductions in plasma theophylline clearance in the acute phase of the illness such that a dosage regimen standardised during remission may cause toxicity if continued in the acute episode. It is suggested that monitoring the plasma theophylline levels is desirable in all patients in the acute episode.

摘要

在8名哮喘患者的急性发作期、恢复期和缓解期，分别测定了单次静脉注射氨茶碱后茶碱的药代动力学。平均血浆茶碱清除率（78.6±33.3 ml/kg/h）、血浆茶碱半衰期（4.14±1.36 h）和表观分布容积（0.41±0.066 l/kg）的总体结果与先前发表的值一致。比较急性发作期和缓解期的结果时，任何药代动力学参数均无总体统计学显著差异。然而，某些患者在疾病急性期血浆茶碱清除率降低，因此在缓解期标准化的给药方案如果在急性发作期继续使用可能会导致中毒。建议在急性发作期对所有患者监测血浆茶碱水平。