Department of Flexible and Printable Electronics, LANL-JBNU Engineering Institute-Korea, Jeonbuk National University, Jeonju 54896, Republic of Korea.
Institute of Applied Physics "Nello Carrara", Italian National Research Council, via Madonna del Piano 10, Sesto Fiorentino I-50019, Italy.
Int J Biol Macromol. 2024 Mar;262(Pt 2):129987. doi: 10.1016/j.ijbiomac.2024.129987. Epub 2024 Feb 10.
This paper introduces a novel approach for loading and releasing Rhodamine B (RhB) into the skin using minimally-invasive microneedle technology developed through digital light-processing (DLP) printing. Notably, this process involves the direct 3D fabrication of rigid microneedle arrays affixed to a flexible patch, marking a pioneering application of DLP printing in this context. The stretchable and durable design of the microneedle substrate enables it to adapt to dynamic movements associated with human activities. Moreover, the microneedle features a pore on each side of the pyramid needle, effectively optimizing its drug-loading capabilities. Results indicate that the microneedle patch can withstand up to 50 % strain without failure and successfully penetrates rat skin. In vitro drug release profiles, conducted through artificial and rat skin, were observed over a 70 h period. This study establishes the potential of a simple manufacturing process for the creation of pore-designed microneedle arrays with a stretchable substrate, showcasing their viability in transdermal drug delivery applications.
本文介绍了一种使用数字光处理（DLP）打印技术开发的微创微针技术将罗丹明 B（RhB）载入皮肤并释放的新方法。值得注意的是，该过程涉及直接 3D 制造刚性微针阵列，这些微针阵列固定在柔性贴片上，标志着 DLP 打印在这方面的开创性应用。微针基底的可拉伸和耐用设计使其能够适应与人活动相关的动态运动。此外，微针在金字塔针的每一侧都有一个孔，有效地优化了其药物负载能力。结果表明，微针贴剂在不失效的情况下可承受高达 50%的应变，并成功穿透大鼠皮肤。通过人工和大鼠皮肤进行的体外药物释放曲线在 70 小时内进行了观察。本研究建立了一种简单制造工艺的潜力，用于创建具有可拉伸基底的孔设计微针阵列，并展示了它们在透皮药物输送应用中的可行性。
