State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, 610041, China.
J Control Release. 2022 Oct;350:933-948. doi: 10.1016/j.jconrel.2022.08.022. Epub 2022 Sep 26.
Microneedle arrays provide an efficient tool for transdermal drug delivery in a minimally invasive and painless manner, showing great potential applications in medicine. However, it remains challenging to fabricate the desired microneedle arrays, because of their micron-scale size and fine structure. Novel manufacturing technologies are very wanted for the development of microneedle arrays, which would solidly advance the clinical translation of microneedle arrays. 3D printing technology is a powerful manufacturing technology with superiority in fabricating personalized and complex structures. Currently, 3D printing technology has been employed to fabricate microneedle arrays, which could push more microneedle arrays into clinic and inspire the development of future microneedle arrays. This work reviews the art of 3D printing microneedle arrays, the benefits of fabricating microneedle arrays with 3D printing, and the considerations for clinical translation of 3D-printed microneedle arrays. This work provides an overview of the current 3D-printed microneedle arrays in drug delivery.
微针阵列以微创、无痛的方式为经皮药物输送提供了一种有效的工具，在医学领域具有很大的应用潜力。然而，由于其微米级的尺寸和精细结构，制造所需的微针阵列仍然具有挑战性。新型制造技术是微针阵列发展的迫切需要，这将有力地推动微针阵列的临床转化。3D 打印技术是一种具有制造个性化和复杂结构优势的强大制造技术。目前，3D 打印技术已被用于制造微针阵列，这将推动更多的微针阵列进入临床，并激发未来微针阵列的发展。本文综述了 3D 打印微针阵列的技术，用 3D 打印制造微针阵列的优势，以及 3D 打印微针阵列临床转化的考虑因素。本文综述了 3D 打印在药物输送中的微针阵列的最新进展。
