a Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology , University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg , Mannheim , Germany.
Expert Opin Ther Targets. 2018 Dec;22(12):983-991. doi: 10.1080/14728222.2018.1538359. Epub 2018 Oct 26.
SOX2 is a transcription factor that is important in the development and maintenance of the stem cell state. Furthermore, SOX2 is associated with cancer progression because it promotes the migration, invasion, and proliferation of cancer cells. SOX2 is also expressed in cancer stem cells and appears to be involved in the resistance toward anticancer therapies. These features render SOX2 an attractive target for cancer therapy. Areas covered: In this review, we highlight the role of SOX2 in cancer and in the resistance toward anticancer therapies. We summarize recent studies dealing with SOX2 as a direct or indirect therapeutic target in cancer. Expert opinion: SOX2 is an attractive target in cancer therapy because of its role in cancer progression and therapy resistance. SOX2 is a transcription factor, hence direct targeting is difficult. Studies aimed at a functional depletion, for example by knock-down with siRNAs, are difficult to translate into clinical settings. Alternatively, the identification of SOX2 upstream or downstream regulators that are easier to target is of paramount importance.
SOX2 是一种转录因子，在干细胞状态的发育和维持中起着重要作用。此外，SOX2 与癌症进展有关，因为它促进癌细胞的迁移、侵袭和增殖。SOX2 也在癌症干细胞中表达，似乎参与了对癌症治疗的耐药性。这些特征使 SOX2 成为癌症治疗的一个有吸引力的靶点。
在这篇综述中，我们强调了 SOX2 在癌症中和在对抗癌治疗的耐药性中的作用。我们总结了最近关于 SOX2 作为癌症的直接或间接治疗靶点的研究。
SOX2 是癌症治疗中一个有吸引力的靶点，因为它在癌症进展和治疗耐药性中起作用。SOX2 是一种转录因子，因此直接靶向治疗很困难。旨在通过 siRNA 敲低等方法实现功能耗竭的研究很难转化为临床环境。另一方面，确定更容易靶向的 SOX2 上游或下游调节剂至关重要。
