Department of Laboratory Animal Science, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Türkiye.
Faculty of Medicine, Department of Biochemistry, Demiroglu Bilim University, Istanbul, Türkiye.
Biol Trace Elem Res. 2024 Dec;202(12):5572-5579. doi: 10.1007/s12011-024-04099-3. Epub 2024 Feb 12.
Boron is primarily used in industrial applications, with recent interest revolving around its effects on metabolism. In this study, we administered boric acid (BA), which has positive effects on reproduction, in conjunction with feed supplementation to serve as a model for experimental animal development and breeding. The pregnancy performance, offspring development, and biochemical effects of mice given feed supplemented with BA at concentrations of 0 (control group), 250, and 500 ppm (BA groups) were investigated. A total of 18 female Balb-C mice were utilized for pregnancy. The mice were given the BA-supplemented feed during a period encompassing three weeks of pregnancy and three weeks of lactation. The numbers and weights of offspring born in cages on days 19-21 were determined. Blood and tissue samples were collected from the offspring during the third week postnatal, and the malondialdehyde (MDA) and total antioxidant and oxidant status (TAS, TOS, and OSI) levels were determined. A significant increase in female offspring was observed in the groups born to mice fed with BA compared to the control group. Positive development in organ weights was observed in the 250-ppm BA group. The 250-ppm group exhibited a significant increase in TAS compared to the control group, while TOS and MDA levels showed a decrease. Also, the levels of BA groups were found to decrease in both the OSI index serum and organ samples compared to the control group. Thus, the use of 250-ppm BA demonstrated positive effects on female offspring production, organ development, and antioxidant levels.
硼主要用于工业应用，最近的研究兴趣集中在其对代谢的影响上。在这项研究中，我们给予硼酸（BA），它对生殖有积极的影响，与饲料补充结合，作为实验动物开发和繁殖的模型。我们研究了给予浓度为 0（对照组）、250 和 500ppm（BA 组）的 BA 饲料补充的小鼠的妊娠表现、后代发育和生化效应。共有 18 只雌性 Balb-C 小鼠用于妊娠。在妊娠的三周和哺乳期的三周期间，给小鼠喂食 BA 补充饲料。确定了第 19-21 天在笼中出生的后代的数量和体重。在产后第三周从后代收集血液和组织样本，并测定丙二醛（MDA）和总抗氧化和氧化状态（TAS、TOS 和 OSI）水平。与对照组相比，喂食 BA 的母鼠所生的雌性后代数量明显增加。在 250ppm BA 组中观察到器官重量的正向发育。与对照组相比，250ppm 组的 TAS 显著增加，而 TOS 和 MDA 水平下降。此外，与对照组相比，BA 组的血清和器官样本中的 OSI 指数均降低。因此，使用 250ppm 的 BA 对雌性后代的生产、器官发育和抗氧化水平表现出积极的影响。
