Govindaraju Lavanya, Jeevanandan Ganesh
Department of Pediatric and Preventive Dentistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Int J Clin Pediatr Dent. 2023 Nov-Dec;16(6):800-803. doi: 10.5005/jp-journals-10005-2721.
Endodontics in primary teeth has brought a revolution in preserving the primary teeth until it is physiological exfoliation. However, reinfection and failure of the pulpectomy-treated teeth should not be neglected. This raises the need for the best root canal filling material with the strongest antibacterial capabilities for primary teeth. The current study set out to assess the antimicrobial efficacy of different concentrations of the novel obturating material against and , the two most common microorganisms found in primary tooth infections.
The antimicrobial efficacy of the novel obturating material was evaluated against and using Mueller-Hinton agar (MHA) for 24 hours at 37°C. Twelve distinct concentrations of the material were prepared by varying the proportions of calcium hydroxide, zinc oxide, and metronidazole. After a day, the zone of inhibition was measured in millimeters. After entering the input into a Microsoft Excel spreadsheet, the values underwent statistical analysis.
The mean zone of inhibition against and was greater with 2% 60-40 concentration of the novel obturating material. However, no statistically significant difference was noted ( = 0.74, 0.22, respectively).
The most effective formulation of the novel obturating material with the greatest antimicrobial property was determined to be 2% 60-40 concentration of metronidazole, calcium hydroxide, and zinc oxide.
Govindaraju L, Jeevanandan G. Development of an Advanced Material for Obturation in Primary Teeth Based on the Microbiological Analysis of the Antimicrobial Efficacy of Various Concentrations: An Study. Int J Clin Pediatr Dent 2023;16(6):800-803.
乳牙牙髓病学在保留乳牙直至其生理性脱落方面带来了一场革命。然而，根管治疗后牙齿的再感染和失败不应被忽视。这就需要为乳牙找到具有最强抗菌能力的最佳根管充填材料。本研究旨在评估不同浓度的新型充填材料对乳牙感染中最常见的两种微生物——变形链球菌和远缘链球菌的抗菌效果。
使用穆勒-欣顿琼脂（MHA）在37℃下对新型充填材料针对变形链球菌和远缘链球菌的抗菌效果进行24小时评估。通过改变氢氧化钙、氧化锌和甲硝唑的比例制备了该材料的12种不同浓度。一天后，以毫米为单位测量抑菌圈。将数据输入Microsoft Excel电子表格后，对这些值进行统计分析。
新型充填材料2% 60 - 40浓度对变形链球菌和远缘链球菌的平均抑菌圈更大。然而，未观察到统计学上的显著差异（分别为P = 0.74，0.22）。
经测定，新型充填材料具有最强抗菌性能的最有效配方为2% 60 - 40浓度的甲硝唑、氢氧化钙和氧化锌。
Govindaraju L, Jeevanandan G.基于不同浓度抗菌效果的微生物学分析开发用于乳牙充填的先进材料：一项体外研究。《国际临床儿科牙科学杂志》2023；16(6)：800 - 803。
