Roschlau G
Zentralbl Allg Pathol. 1985;130(6):519-24.
As a result of the ability to examine successive biopsy specimens, the process of progression of liver damage resulting from ethanol abuse is well appreciated. The ten most important tissue and cellular changes are described in the present paper. The staging system promulgated by the author since 1977 is reviewed: 1) Alcohol-induced liver damage without fibrosis, 2) Alcoholic hepatopathy with fibrosis, 3) Alcoholic hepatopathy with cirrhosis. Staging by this system provides clinically valuable prognostic information. Women with stage 1 changes have a two to threefold liklihood of advancing to stage 3 than do men with the same degree of initial damage.
由于能够检查连续的活检标本，乙醇滥用导致的肝损伤进展过程已得到充分认识。本文描述了十个最重要的组织和细胞变化。回顾了作者自1977年以来颁布的分期系统：1）无纤维化的酒精性肝损伤，2）伴有纤维化的酒精性肝病，3）伴有肝硬化的酒精性肝病。通过该系统进行分期可提供具有临床价值的预后信息。与具有相同初始损伤程度的男性相比，处于1期变化的女性进展到3期的可能性高出两到三倍。
