Moia Melissa Nunes, Lima Severina Carla Vieira Cunha, da Silva Nunes Francisca Leide, Queiroz Salomão Israel Monteiro Lourenço, Marchioni Dirce Maria Lobo, Pedrosa Lucia Fátima Campos, Barbosa Fernando, de Oliveira Lyra Clélia, Sena-Evangelista Karine Cavalcanti Maurício
Postgraduate Program in Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho 3000 - Lagoa Nova, Natal, Rio Grande do Norte, 59078-900, Brazil.
Department of Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho 3000 - Lagoa Nova, Natal, Rio Grande do Norte, 59078-900, Brazil.
Biol Trace Elem Res. 2024 Dec;202(12):5307-5318. doi: 10.1007/s12011-024-04088-6. Epub 2024 Feb 12.
Magnesium and calcium are elements that have been associated with cardiometabolic risk factors related to metabolic syndrome (MetS). However, there are gaps in the knowledge regarding the impact of the calcium to magnesium (Ca/Mg) ratio in plasma. Thus, we aim to evaluate the associations between magnesium and calcium levels in plasma, and the Ca/Mg ratio in plasma with MetS components and other cardiometabolic risk factors. This cross-sectional study was carried out with 112 adults and older people, distributed into groups with (n = 60) and without MetS (n = 52). We evaluated sociodemographic, anthropometric, and biochemical data. Magnesium and calcium levels in plasma were measured by inductively coupled plasma mass spectrometry technique (ICP-MS). There was a high frequency of MetS, with no significant differences in magnesium and calcium levels and Ca/Mg ratio in plasma observed between groups. There were no associations between magnesium and MetS components or other cardiometabolic risk factors (all p > 0.05). Calcium levels were associated with total cholesterol (β = - 0.020; p = 0.000) and high-density lipoprotein cholesterol (HDL-c) (β = - 0.046; p = 0.005). The total cholesterol (β = - 0.025; p = 0.000) and low-density lipoprotein cholesterol (LDL-c) (β = 0.017; p = 0.020) were preditors of the Ca/Mg ratio. These results indicate important associations of calcium and the Ca/Mg ratio in plasma with cardiometabolic risk factors related to MetS.
镁和钙是与代谢综合征（MetS）相关的心脏代谢危险因素有关的元素。然而，关于血浆中钙镁比（Ca/Mg）的影响，目前仍存在知识空白。因此，我们旨在评估血浆中镁和钙水平以及血浆中Ca/Mg比与MetS组分和其他心脏代谢危险因素之间的关联。这项横断面研究对112名成年人及老年人进行，分为患有（n = 60）和未患有MetS（n = 52）的两组。我们评估了社会人口统计学、人体测量学和生化数据。采用电感耦合等离子体质谱技术（ICP-MS）测量血浆中的镁和钙水平。MetS的发生率较高，两组之间血浆中的镁、钙水平及Ca/Mg比未见显著差异。镁与MetS组分或其他心脏代谢危险因素之间无关联（所有p>0.05）。钙水平与总胆固醇（β = -0.020；p = 0.000）和高密度脂蛋白胆固醇（HDL-c）（β = -0.046；p = 0.005）相关。总胆固醇（β = -0.025；p = 0.000）和低密度脂蛋白胆固醇（LDL-c）（β = 0.017；p = 0.020）是Ca/Mg比的预测因素。这些结果表明，血浆中的钙和Ca/Mg比与MetS相关的心脏代谢危险因素之间存在重要关联。
