Faculty of Medicine and Health Sciences, Department of Rehabilitation Sciences & Physiotherapy, Research group MOVANT, Multi-disciplinary Metabolic Research Unit (M2RUN), University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.
Antwerp University Hospital (UZA), Multidisciplinary Breast Clinic, Wilrijkstraat 10, 2650, Edegem, Belgium.
BMC Womens Health. 2024 Feb 12;24(1):117. doi: 10.1186/s12905-024-02900-y.
This study aimed to investigate the difference in absolute and fat free mass (FFM)-adjusted resting energy expenditure (mREE) and body composition (body weight, fat mass (FM), FFM) between breast cancer survivors (BCs) and controls. Correlations with body composition were analyzed. We examined if survival year, or being metabolically dysfunctional were predictive variables.
A cross-sectional analysis was conducted on 32 BCs ≤5 years post treatment and 36 healthy controls. Indirect calorimetry measured absolute mREE. Body composition was determined by BOD POD. FFM-adjusted mREE was calculated (mREE/FFM). The Harris-Benedict equation was used to predict REE and determine hyper-/hypometabolism (mREE/pREE). The database of the multidisciplinary breast clinic of the University Hospital of Antwerp was consulted for survival year and metabolic dysfunctions.
BCs have similar absolute mREE and greater FFM-adjusted mREE compared to controls. Absolute mREE and body composition between BCs differed; adjusted mREE was similar. FFM correlated significantly with absolute mREE in BCs. A significant interaction term was found between survival year and FM for absolute mREE.
BCs have similar absolute mREE, but higher FFM-adjusted mREE. Differences in body composition between BCs are suggested to cause inter-individual variations. We suggest that increased FFM-adjusted mREE is caused by metabolic stress related to cancer/treatment. Accurate measurement of REE and body composition is advised when adapting nutritional strategies, especially in patients at risk for developing metabolic dysfunctions.
本研究旨在探讨乳腺癌幸存者（BCs）与对照组之间静息能量消耗（REE）的绝对值和去脂体重（FFM）校正值（mREE）以及身体成分（体重、脂肪量（FM）、FFM）的差异。分析了与身体成分的相关性。我们研究了生存年限或代谢功能障碍是否为预测变量。
对 32 名≤5 年乳腺癌治疗后的幸存者和 36 名健康对照组进行了横断面分析。间接热量测定法测量了绝对 mREE。使用 BOD POD 测定身体成分。计算了 FFM 校正的 mREE（mREE/FFM）。使用 Harris-Benedict 方程预测 REE 并确定高代谢/低代谢（mREE/pREE）。咨询了安特卫普大学医院多学科乳房诊所的数据库以获取生存年限和代谢功能障碍的信息。
BCs 的绝对 mREE 相似，但 FFM 校正的 mREE 更高。BCs 之间的绝对 mREE 和身体成分存在差异，而调整后的 mREE 相似。FFM 与 BCs 的绝对 mREE 显著相关。在绝对 mREE 中发现生存年限和 FM 之间存在显著的交互项。
BCs 的绝对 mREE 相似，但 FFM 校正的 mREE 更高。BCs 之间的身体成分差异可能导致个体间的差异。我们认为，增加的 FFM 校正的 mREE 是由与癌症/治疗相关的代谢应激引起的。在调整营养策略时，建议准确测量 REE 和身体成分，特别是在有发生代谢功能障碍风险的患者中。
