Jadhao Pooja, Swain Jayshree, Das Srijit, Mangaraj Swayamsidha, Sravya Surapaneni Lakshmi
Department of Endocrinology, IMS & SUM Medical College and Hospital, Bhubaneswar, Odisha, India.
Department of Human & Clinical Anatomy, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman.
Curr Diabetes Rev. 2025;21(3):13-23. doi: 10.2174/0115733998282818240125110248.
The present study aimed to determine the prevalence and predictors of DPN in newly diagnosed T2DM patients.
Diabetic Peripheral Neuropathy (DPN) is the most common and debilitating complication of Type 2 Diabetes Mellitus (T2DM).
Newly diagnosed T2DM patients visiting the outpatient department were recruited. Detailed demographic parameters, histories, physical examinations, and biochemical investigations were carried out. Patients were screened for DPN using the Diabetic Neuropathy Symptom (DNS) score, the revised Disability Neuropathy Score (NDS), Vibration Perception Threshold (VPT) using a biosthesiometer, and the 10 g SW Monofilament Test (MFT).
A total of 350 newly diagnosed T2DM patients (mean age 46.4±13.6 years) were included. The prevalence of DPN was found to be 34% using the combined DNS and NDS scores. VPT was moderately impaired in 18.3% and severely impaired in 12% patients, while MFT revealed a loss of protective sensation in 35.4% patients. After logistic regression analysis, DPN was significantly associated with increasing age (OR 1.08, 95%CI 1.06-1.11), increasing HbA1C levels (OR 1.23, 95%CI 1.05-1.42), increasing TSH levels (OR 1.23, 95%CI 1.05-1.44), presence of hypertension (OR 2.78, 95%CI 1.51-5.11), and reduced BMI (OR 0.9, 95%CI 0.84- 0.99). The sensitivity and specificity of detecting DPN by combining VPT and MFT were 91.6% and 84.2%, respectively.
The prevalence of DPN was high even in newly diagnosed T2DM and associated significantly with increasing age, HbA1C levels, TSH levels, hypertension, and reduced BMI. Earlier screening for DPN, along with aggressive control of glycemia, blood pressure, and hypothyroidism, may be beneficial.
本研究旨在确定新诊断的2型糖尿病（T2DM）患者中糖尿病周围神经病变（DPN）的患病率及预测因素。
糖尿病周围神经病变（DPN）是2型糖尿病（T2DM）最常见且使人衰弱的并发症。
招募到门诊就诊的新诊断T2DM患者。进行详细的人口统计学参数、病史、体格检查及生化检查。使用糖尿病神经病变症状（DNS）评分、修订的残疾神经病变评分（NDS）、用生物感觉测量仪测量的振动觉阈值（VPT）以及10g单丝试验（MFT）对患者进行DPN筛查。
共纳入350例新诊断的T2DM患者（平均年龄46.4±13.6岁）。采用DNS和NDS综合评分法得出DPN患病率为34%。18.3%的患者VPT中度受损，12%的患者VPT严重受损，而MFT显示35.4%的患者保护性感觉丧失。经逻辑回归分析，DPN与年龄增加（比值比[OR]1.08，95%置信区间[CI]1.06 - 1.11）、糖化血红蛋白（HbA1C）水平升高（OR 1.23，95%CI 1.05 - 1.42）、促甲状腺激素（TSH）水平升高（OR 1.23，95%CI 1.05 - 1.44）、高血压的存在（OR 2.78，95%CI 1.51 - 5.11）以及体重指数（BMI）降低（OR 0.9，95%CI 0.84 - 0.99）显著相关。联合VPT和MFT检测DPN的敏感性和特异性分别为91.6%和84.2%。
即使在新诊断的T2DM患者中，DPN的患病率也很高，且与年龄增加、HbA1C水平、TSH水平、高血压及BMI降低显著相关。早期筛查DPN，同时积极控制血糖、血压和甲状腺功能减退可能有益。
