Mittal Rahul, McKenna Keelin, Keith Grant, McKenna Evan, Lemos Joana R N, Mittal Jeenu, Hirani Khemraj
Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, USA.
Neural Regen Res. 2025 Aug 1;20(8):2218-2230. doi: 10.4103/NRR.NRR-D-24-00270. Epub 2024 Sep 6.
Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this condition. Diabetic peripheral neuropathy, a common complication of diabetes, is characterized by nerve damage due to high blood sugar levels that lead to symptoms, such as pain, tingling, and numbness, primarily in the hands and feet. The aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy, while also examining recent developments in this domain. The investigation encompassed an array of neuromodulation methods, including frequency rhythmic electrical modulated systems, dorsal root ganglion stimulation, and spinal cord stimulation. This systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral neuropathy. Understanding the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic treatments. Through these efforts, we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.
神经调节用于治疗糖尿病性周围神经病变，是该疾病相关慢性疼痛管理中一个备受关注的重要领域。糖尿病性周围神经病变是糖尿病的常见并发症，其特征是由于高血糖水平导致神经损伤，主要引起手部和足部出现疼痛、刺痛和麻木等症状。本系统评价的目的是评估神经调节技术作为糖尿病性周围神经病变患者潜在治疗干预措施的疗效，同时考察该领域的最新进展。该研究涵盖了一系列神经调节方法，包括频率节律性电调制系统、背根神经节刺激和脊髓刺激。本系统评价表明，神经调节技术可能对糖尿病性周围神经病变的治疗有用。了解这些治疗方法的优势将使医生和其他医疗服务提供者能够为对标准药物治疗无效的症状患者提供更多选择。通过这些努力，我们可以提高糖尿病神经病变相关并发症患者的生活质量并增强其功能能力。
