佐剂用于增强头孢西丁在人体直肠吸收的研究。
Use of adjuvants for enhancement of rectal absorption of cefoxitin in humans.
作者信息
Davis S S, Burnham W R, Wilson P, O'Brien J
出版信息
Antimicrob Agents Chemother. 1985 Aug;28(2):211-5. doi: 10.1128/AAC.28.2.211.
Abstract
The biological availability of cefoxitin administered rectally in the form of suppositories was examined in six human subjects by a cross-over design. Four different suppository systems containing adjuvants expected to enhance the absorption of the drug were studied. The presence of sodium salicylate and a nonionic surface-active agent, Brij 35, gave increased bioavailability as high as 20% compared with 3% for a system without adjuvants. The quantity of sodium salicylate was found to have an influence on the quantity of cefoxitin absorbed, and the salicylate was absorbed over an extended period of time from the rectum. The suppositories were well tolerated, and there were no adverse effects on bowel flora.
摘要
采用交叉设计在6名人体受试者中研究了以栓剂形式直肠给药的头孢西丁的生物利用度。研究了四种不同的含有预期可增强药物吸收的佐剂的栓剂系统。与不含佐剂的系统相比，水杨酸钠和非离子表面活性剂Brij 35的存在使生物利用度提高了高达20%，而不含佐剂的系统生物利用度为3%。发现水杨酸钠的量对头孢西丁的吸收量有影响，水杨酸盐从直肠吸收的时间较长。这些栓剂耐受性良好，对肠道菌群没有不良影响。
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