Ma Wen, Liu Youhan, Meng Chang, Luo Ying, Wang Qinglu
College of Sport and Health, Shandong Sport University, Jinan, Shandong 250102, China.
Key Laboratory of Biomedical Engineering & Technology of Shandong High School, Qilu Medical University, Zibo 255213, China.
Data Brief. 2024 Feb 1;53:110134. doi: 10.1016/j.dib.2024.110134. eCollection 2024 Apr.
Studies on the crosstalk between muscle and adipose tissue can provide beneficial help in elucidating the pathogenesis and treatment of obesity-related diseases [1]. In this data article, we performed RNA sequence analysis of mRNA isolated from epididymal adipose tissue and gastrocnemius muscle tissue in obese rats. Twenty-two samples were selected for gene expression analysis. Raw data from the Illumina Hiseq™ platform sequencer was used for differential gene expression analysis using DESeq and deposited in the GEO public repository under accession number GSE237950. With the economic development and the change of people's lifestyle, obesity has become a major public health problem that endangers global health. Obesity is a metabolic disorder caused by excessive accumulation of white adipose tissue, which can further induce metabolic syndrome such as insulin resistance, type 2 diabetes, and cardiovascular and cerebrovascular diseases. Studies have shown that altitude hypoxic exercise can not only improve muscle buffering capacity and body performance, but also reduce body weight and body fat more significantly. In many countries, it has been used as a treatment program for obesity diseases [2]. Hypoxic exercise can improve lipid metabolism, reduce blood lipid levels, inhibit fatty acid synthesis, and promote fatty acid decomposition and oxidation, which is the mechanism of hypoxic exercise to significantly reduce weight and fat. However, the mechanism of the cross-talk between muscle and fat tissue is not well understood under hypoxia exercise and normoxia exercise conditions. The data contained rat's four different states: normoxia quiet, normoxia exercise, hypoxic quiet, and hypoxic exercise. RNA-seq data will provide insights into the cross-talk between muscle and fat, and the mechanisms of fat metabolism. The data of this study have not been published and are hereby published on this platform to study the cross talk between muscle tissue and adipose tissue in rats under different oxygen content and exercise environment.
肌肉与脂肪组织之间的串扰研究有助于阐明肥胖相关疾病的发病机制及治疗方法[1]。在本数据文章中，我们对肥胖大鼠附睾脂肪组织和腓肠肌组织分离出的mRNA进行了RNA序列分析。选取22个样本进行基因表达分析。Illumina Hiseq™平台测序仪的原始数据用于使用DESeq进行差异基因表达分析，并以登录号GSE237950存入GEO公共数据库。随着经济发展和人们生活方式的改变，肥胖已成为危害全球健康的主要公共卫生问题。肥胖是一种由白色脂肪组织过度堆积引起的代谢紊乱，可进一步诱发胰岛素抵抗、2型糖尿病以及心脑血管疾病等代谢综合征。研究表明，高原低氧运动不仅能提高肌肉缓冲能力和身体机能，还能更显著地减轻体重和体脂。在许多国家，它已被用作肥胖疾病的治疗方案[2]。低氧运动可改善脂质代谢、降低血脂水平、抑制脂肪酸合成，并促进脂肪酸分解和氧化，这是低氧运动显著减轻体重和脂肪的机制。然而，在低氧运动和常氧运动条件下，肌肉与脂肪组织之间的串扰机制尚不清楚。数据包含大鼠的四种不同状态：常氧安静、常氧运动、低氧安静和低氧运动。RNA测序数据将为肌肉与脂肪之间的串扰以及脂肪代谢机制提供见解。本研究的数据尚未发表，特此在本平台发表，以研究不同氧含量和运动环境下大鼠肌肉组织与脂肪组织之间的串扰。
