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早衰蛋白基因敲除小鼠在症状出现前肝脏、骨骼、心脏、肾脏和血液的RNA测序转录组数据以及日本传统多草药方剂十全大补汤的作用。

Data of RNA-seq transcriptomes of liver, bone, heart, kidney and blood in klotho mice at a pre-symptomatic state and the effect of a traditional Japanese multi-herbal medicine, juzentaihoto.

作者信息

Okada Norihiro, Oshima Kenshiro, Iwasaki Yuki, Maruko Akiko, Matsumura Kenya, Iioka Erica, Vu Trieu-Duc, Fujitsuka Naoki, Nishi Akinori, Sugiyama Aiko, Nishiyama Mitsue, Kaneko Atsushi, Mizoguchi Kazushige, Yamamoto Masahiro, Nishimura Susumu

机构信息

School of Pharmacy, Kitasato University, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa 252- 0373 Japan.

Foundation for Advancement of International Science (FAIS) , 3-24-16 Kasuga, Tsukuba, Ibaraki 305-0821 Japan.

出版信息

Data Brief. 2022 Apr 22;42:108197. doi: 10.1016/j.dib.2022.108197. eCollection 2022 Jun.

DOI:10.1016/j.dib.2022.108197
PMID:35515992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9065611/
Abstract

We performed RNA-seq analyses of mRNA isolated from five organs, liver, bone, heart, kidney and blood at the pre-symptomatic state of klotho mice with/without administration of a Japanese traditional herbal medicine, juzentaihoto (JTT). Data of differentially expressed genes (DEG) with/without JTT was included. Intron retention (IR) is an important regulatory mechanism that affects gene expression and protein functions. We collected data in which retained-introns were accumulated in a particular set of genes of these organs, and showed that among these retained introns in the liver and bone a subset was recovered to the normal state by the medicine. All of the data present changes of molecular events on the levels of metabolites, proteins and gene expressions observed at the pre- symptomatic state of aging in klotho mice with/without JTT. The research article related to this Data in Brief is published in GENE entitled as "Intron retention as a new pre-symptomatic marker of aging and its recovery to the normal state by a traditional Japanese herbal medicine".

摘要

我们对从处于症状前期的klotho小鼠的五个器官（肝脏、骨骼、心脏、肾脏和血液）中分离出的mRNA进行了RNA测序分析，这些小鼠分别给予/未给予日本传统草药十全大补汤（JTT）。纳入了给予/未给予JTT情况下的差异表达基因（DEG）数据。内含子保留（IR）是一种影响基因表达和蛋白质功能的重要调控机制。我们收集了在这些器官的特定基因集中内含子保留累积的数据，并表明在肝脏和骨骼中的这些保留内含子中，一部分通过该药物恢复到了正常状态。所有数据呈现了在给予/未给予JTT的klotho小鼠衰老症状前期观察到的代谢物、蛋白质和基因表达水平上分子事件的变化。与本简要数据相关的研究文章发表在《基因》杂志上，标题为“内含子保留作为衰老的一种新的症状前标志物及其被日本传统草药恢复到正常状态” 。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced8/9065611/ecec4f71d210/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced8/9065611/007a0622cf75/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced8/9065611/10f23459a7a6/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced8/9065611/a24f40fd1ef6/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced8/9065611/4cca28fbf116/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced8/9065611/f73ec9781425/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced8/9065611/1e1b61f32128/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced8/9065611/3f10b46f83ce/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced8/9065611/2a34a189a905/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced8/9065611/ecec4f71d210/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced8/9065611/007a0622cf75/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced8/9065611/10f23459a7a6/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced8/9065611/a24f40fd1ef6/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced8/9065611/4cca28fbf116/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced8/9065611/f73ec9781425/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced8/9065611/1e1b61f32128/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced8/9065611/3f10b46f83ce/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced8/9065611/2a34a189a905/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced8/9065611/ecec4f71d210/gr9.jpg

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