Horpácsy G, Schuldt H H, Althaus P, May G, Mebel M
Eur Surg Res. 1979;11(1):39-49. doi: 10.1159/000128050.
The effect of prednisone therapy on renal hemodynamics was studied in normal, autotransplanted as well as homotransplanted dog kidneys. After intravenous administration of prednisone (8 and 16 mg/kg/min) the total blood flow decreased and vascular resistance increased significantly. This effect was more pronounced if the drug was directly injected into the arteria renalis. The same changes were observed in autotransplanted and homotransplanted kidneys and in kidneys in rejection. Our results suggest that high dosage of prednisone decreases the renal blood flow and this adverse effect has to be considered in the therapy. The administration of the drug directly into the arteria renalis may have to be avoided.
在正常犬肾、自体移植肾以及同种异体移植肾中研究了泼尼松治疗对肾血流动力学的影响。静脉注射泼尼松（8和16毫克/千克/分钟）后，总血流量下降，血管阻力显著增加。如果将药物直接注入肾动脉，这种作用会更明显。在自体移植肾、同种异体移植肾以及处于排斥反应的肾中观察到了相同的变化。我们的结果表明，高剂量的泼尼松会降低肾血流量，在治疗中必须考虑到这种不良反应。可能必须避免将药物直接注入肾动脉。
