Mavridou Konstantina, Karakasi Aggeliki, Lampri Evangeli, Gaitanis George, Bassukas Ioannis D
Department of Dermatology, University Hospital of Ioannina.
Department of Pathology.
Dermatol Reports. 2023 Aug 10;15(4):9761. doi: 10.4081/dr.2023.9761. eCollection 2023 Dec 1.
Bleomycin, an antineoplastic antibiotic that inhibits DNA synthesis, is used to treat various malignant tumors such as Hodgkin's lymphoma, squamous cell carcinoma, and germ cell tumors. Flagellate erythema is a rare rash with a linear pattern that has been observed in association with bleomycin treatment. Herein, we present a 43-year-old patient with metastatic testicular cell neoplasms who developed a whiplash rash during treatment with a chemotherapy regimen that included bleomycin. A typical case of bleomycin-related flagellate dermatitis has been diagnosed and the main features of this characteristic adverse drug event are briefly discussed.
博来霉素是一种抑制DNA合成的抗肿瘤抗生素,用于治疗各种恶性肿瘤,如霍奇金淋巴瘤、鳞状细胞癌和生殖细胞肿瘤。鞭状红斑是一种罕见的皮疹,呈线状,已观察到与博来霉素治疗有关。在此,我们报告一名43岁患有转移性睾丸细胞瘤的患者,在接受包括博来霉素的化疗方案治疗期间出现了挥鞭样皮疹。已诊断出一例典型的博来霉素相关鞭状皮炎病例,并简要讨论了这一特征性药物不良事件的主要特征。