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博来霉素诱发的鞭毛虫样皮炎:再探讨

Bleomycin-Induced Flagellate Dermatitis: Revisited.

作者信息

Verma Pallavi, Rajaram Shalini, Heda Ayush, Sundriyal Deepak, Tiwari Parmita, Sahoo Ipshita, Panta Shilpa, Bordoloi Mriganka, Bhan Himani, Sharma Dipendra

机构信息

Obstetrics and Gynaecology (Gynaecologic Oncology), All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.

Medical Oncology, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.

出版信息

Cureus. 2022 Sep 16;14(9):e29221. doi: 10.7759/cureus.29221. eCollection 2022 Sep.

DOI:10.7759/cureus.29221
PMID:36258994
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9571210/
Abstract

Flagellate dermatitis caused by bleomycin is a rare side effect with a distinctive pattern of whip-like, linear streaks. The clinical presentation has become uncommon nowadays as bleomycin use in conventional chemotherapy regimens has decreased. We present a case of a 30-year-old female diagnosed with ovarian germ cell tumour, managed with bleomycin, etoposide, and cisplatin (BEP) and later developed a widespread rash indicative of classic flagellate dermatitis. This brief report emphasizes the significance of detection and management of this transient dermatological complication in patients receiving bleomycin.

摘要

博来霉素引起的鞭毛虫样皮炎是一种罕见的副作用,具有独特的鞭状线性条纹图案。如今,随着博来霉素在传统化疗方案中的使用减少,其临床表现已不常见。我们报告一例30岁女性,被诊断为卵巢生殖细胞肿瘤,接受博来霉素、依托泊苷和顺铂(BEP)治疗,后来出现了广泛的皮疹,提示典型的鞭毛虫样皮炎。本简要报告强调了在接受博来霉素治疗的患者中检测和处理这种短暂性皮肤并发症的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ed/9571210/61a40dcd89c6/cureus-0014-00000029221-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ed/9571210/640fc862f739/cureus-0014-00000029221-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ed/9571210/61a40dcd89c6/cureus-0014-00000029221-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ed/9571210/640fc862f739/cureus-0014-00000029221-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ed/9571210/61a40dcd89c6/cureus-0014-00000029221-i02.jpg

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[Flagellate erythema secondary to bleomycin: case report with favorable outcome].[博来霉素继发的鞭毛状红斑:预后良好的病例报告]
Rev Med Inst Mex Seguro Soc. 2025 May 2;63(3):e6585. doi: 10.5281/zenodo.15178515.
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Recognizing Flagellate Erythema in Skin of Color: A Case of Shiitake Dermatitis.识别有色人种皮肤中的鞭毛虫红斑:一例香菇性皮炎病例。
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本文引用的文献

1
Bleomycin-Induced Flagellate Dermatitis.博来霉素诱发的鞭毛虫性皮炎。
Turk J Haematol. 2019 May 3;36(2):138-140. doi: 10.4274/tjh.galenos.2019.2018.0317. Epub 2019 Jan 2.
2
Bleomycin-Induced Flagellate Erythema in a Patient Diagnosed with Ovarian Yolk Sac Tumor.一名被诊断为卵巢卵黄囊瘤的患者出现博来霉素诱导的鞭毛虫样红斑。
Case Rep Oncol Med. 2015;2015:574708. doi: 10.1155/2015/574708. Epub 2015 Dec 21.
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Bleomycin-induced flagellate erythema in a patient with Hodgkin's lymphoma - A case report and review of literature.一名霍奇金淋巴瘤患者发生博来霉素诱导的鞭毛虫样红斑——病例报告及文献复习
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Flagellate dermatitis as a bleomycin-specific adverse effect of cytostatic therapy: a clinical-histopathologic correlation.鞭毛样皮炎作为细胞毒性药物治疗的博莱霉素特异性不良反应:临床-组织病理学相关性。
Am J Clin Dermatol. 2011 Feb 1;12(1):68-76. doi: 10.2165/11537080-000000000-00000.
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Flagellate erythema induced by docetaxel.多西他赛引起的鞭毛虫样红斑。
Clin Exp Dermatol. 2008 May;33(3):276-7. doi: 10.1111/j.1365-2230.2007.02633.x. Epub 2008 Jan 14.
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Bleomycin-induced flagellate erythema.
J Clin Oncol. 2007 Mar 1;25(7):898-900. doi: 10.1200/JCO.2006.09.7691.
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[Cutaneous pigmentation caused by bleomycin].[博来霉素引起的皮肤色素沉着]
Bull Soc Fr Dermatol Syphiligr. 1970;77(2):293-6.